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\u6574\u7406<\/p>\n\n\n\n<p><strong>\u6458\u8981<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u672c\u5831\u544a\u65e8\u5728\u5c0d\u6240\u63d0\u51fa\u7684\u300c\u7761\u7720-\u80fd\u91cf\u8abf\u63a7\u6a21\u578b\u300d\u9032\u884c\u6df1\u5165\u7684\u79d1\u5b78\u5be9\u8996\u8207\u4fee\u6b63\uff0c\u8a72\u6a21\u578b\u65e8\u5728\u6574\u5408\u5206\u5b50\u751f\u7269\u5b78\u8b49\u64da\uff0c\u5c07\u6a5f\u5236\u5ef6\u4f38\u81f3\u7126\u616e\u8207\u6291\u9b31\u75c7\u7684\u8eab\u5fc3\u6cbb\u7642\uff0c\u4e26\u69cb\u5efa\u5f9e\u795e\u7d93\u5143\u5230\u5168\u8eab\u8abf\u7bc0\u7684\u79d1\u5b78\u6846\u67b6\u3002\u5831\u544a\u5c07\u63ed\u793a\u539f\u59cb\u6a21\u578b\u4e2d\u5b58\u5728\u7684\u79d1\u5b78\u4e0d\u6e96\u78ba\u4e4b\u8655\uff0c\u7279\u5225\u662f\u91dd\u5c0d\u672a\u4f86\u5e74\u4efd\u7684\u6587\u737b\u5f15\u7528\u548c\u5177\u9ad4\u91cf\u5316\u6578\u64da\u7684\u8072\u7a31\u3002\u57fa\u65bc\u73fe\u6709\u79d1\u5b78\u8b49\u64da\uff0c\u5831\u544a\u5c07\u63d0\u4f9b\u7cbe\u78ba\u7684\u4fee\u6b63\u5efa\u8b70\uff0c\u4e26\u6df1\u5165\u63a2\u8a0e\u7126\u616e\u8207\u6291\u9b31\u75c7\u7684\u5171\u540c\u5206\u5b50\u75c5\u7406\u3001\u4e2d\u85e5\u6cbb\u7642\u7684\u6f5b\u5728\u6a5f\u5236\u3001\u8207\u897f\u85e5\u6cbb\u7642\u7684\u5206\u5b50\u512a\u52e2\u5c0d\u6bd4\uff0c\u4ee5\u53ca\u81e8\u5e8a\u8f49\u5316\u61c9\u7528\u7684\u53ef\u884c\u6027\u3002\u5831\u544a\u5f37\u8abf\uff0c\u5118\u7ba1\u8a72\u6a21\u578b\u5728\u6574\u5408\u591a\u7cfb\u7d71\u75c5\u7406\u65b9\u9762\u5177\u6709\u5275\u65b0\u6f5b\u529b\uff0c\u4f46\u5176\u90e8\u5206\u5177\u9ad4\u6a5f\u5236\u548c\u91cf\u5316\u9810\u671f\u4ecd\u9700\u66f4\u56b4\u8b39\u7684\u5be6\u8b49\u652f\u6301\u3002<\/p>\n\n\n\n<p><strong>\u524d\u8a00\uff1a\u7761\u7720<\/strong><strong>&#8211;<\/strong><strong>\u80fd\u91cf\u8abf\u63a7\u6a21\u578b\u4e4b\u79d1\u5b78\u6846\u67b6<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u7126\u616e\u75c7\u8207\u6291\u9b31\u75c7\u662f\u5168\u7403\u7bc4\u570d\u5167\u666e\u904d\u4e14\u8ca0\u64d4\u6c89\u91cd\u7684\u795e\u7d93\u7cbe\u795e\u75be\u75c5\uff0c\u5176\u8907\u96dc\u7684\u75c5\u7406\u751f\u7406\u5b78\u6a5f\u5236\u5c0e\u81f4\u73fe\u6709\u6cbb\u7642\u624b\u6bb5\u9762\u81e8\u8af8\u591a\u6311\u6230\uff0c\u5305\u62ec\u8d77\u6548\u5ef6\u9072\u3001\u526f\u4f5c\u7528\u4ee5\u53ca\u9ad8\u975e\u61c9\u7b54\u7387 <sup>1<\/sup>\u3002\u4f8b\u5982\uff0c\u91cd\u5ea6\u6291\u9b31\u75c7 (MDD) \u60a3\u8005\u4e2d\u9ad8\u905427%\u4f34\u6709\u795e\u7d93\u708e\u75c7\uff0c\u9019\u8207\u66f4\u56b4\u91cd\u3001\u6162\u6027\u5316\u53ca\u6cbb\u7642\u62b5\u6297\u7684\u75be\u75c5\u9032\u7a0b\u76f8\u95dc <sup>3<\/sup>\u3002\u6b64\u5916\uff0c\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u88ab\u5ee3\u6cdb\u8b49\u5be6\u8207\u591a\u7a2e\u7cbe\u795e\u75be\u75c5\u548c\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u7684\u75c5\u7406\u751f\u7406\u5b78\u76f8\u95dc\uff0c\u9019\u63d0\u793a\u4e86\u591a\u7cfb\u7d71\u5931\u8861\u5728\u9019\u4e9b\u75be\u75c5\u4e2d\u7684\u6838\u5fc3\u4f5c\u7528 <sup>4<\/sup>\u3002<\/p>\n\n\n\n<p>\u9019\u4e9b\u89c0\u5bdf\u7d50\u679c\u8868\u660e\uff0c\u7126\u616e\u548c\u6291\u9b31\u75c7\u4e26\u975e\u55ae\u4e00\u7cfb\u7d71\u5931\u8861\u7684\u7d50\u679c\uff0c\u800c\u662f\u80fd\u91cf\u3001\u795e\u7d93\u3001\u514d\u75ab\u7b49\u591a\u500b\u751f\u7269\u7cfb\u7d71\u76f8\u4e92\u4f5c\u7528\u3001\u5f7c\u6b64\u5f71\u97ff\u7684\u8907\u96dc\u75c5\u7406\u904e\u7a0b\u3002\u56e0\u6b64\uff0c\u672c\u5831\u544a\u6240\u5be9\u8996\u7684\u300c\u7761\u7720-\u80fd\u91cf\u8abf\u63a7\u6a21\u578b\u300d\u63a1\u7528\u7cfb\u7d71\u7d1a\u6574\u5408\u65b9\u6cd5\uff0c\u4e0d\u50c5\u5728\u7406\u8ad6\u4e0a\u5177\u6709\u5275\u65b0\u6027\uff0c\u66f4\u7b26\u5408\u751f\u7269\u5b78\u73fe\u5be6\uff0c\u70ba\u7406\u89e3\u548c\u6cbb\u7642\u9019\u4e9b\u8907\u96dc\u75be\u75c5\u63d0\u4f9b\u4e86\u66f4\u5168\u9762\u7684\u8996\u89d2\u3002\u8a72\u6a21\u578b\u5c07\u80fd\u91cf\u4ee3\u8b1d\uff08\u7dda\u7c92\u9ad4\u529f\u80fd\u3001ATP\u751f\u6210\uff09\u3001GABA\u80fd\u7cfb\u7d71\u53ca\u795e\u7d93\u708e\u75c7\u5217\u70ba\u5171\u540c\u75c5\u7406\u57fa\u790e\uff0c\u70ba\u958b\u767c\u91dd\u5c0d\u75be\u75c5\u6839\u6e90\u7684\u6cbb\u7642\u65b9\u6848\u63d0\u4f9b\u4e86\u6f5b\u5728\u7684\u7406\u8ad6\u6846\u67b6\u3002<\/p>\n\n\n\n<p><strong>\u7b2c\u4e00\u7ae0\uff1a\u7126\u616e\u6291\u9b31\u7684\u5171\u7528\u5206\u5b50\u75c5\u7406\uff1a\u8a55\u4f30\u8207\u79d1\u5b78\u4fee\u6b63<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>\u80fd\u91cf\u4ee3\u8b1d\u5d29\u6f70<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u80fd\u91cf\u4ee3\u8b1d\u5931\u8861\u662f\u7126\u616e\u8207\u6291\u9b31\u75c7\u75c5\u7406\u5b78\u4e2d\u7684\u4e00\u500b\u95dc\u9375\u74b0\u7bc0\u3002<\/p>\n\n\n\n<p><strong>ATP\/ADP <\/strong><strong>\u6301\u7e8c\u4f4e\u6bd4\u503c\u8207\u524d\u984d\u8449\u76ae\u5c64\u7dda\u7c92\u9ad4\u8907\u5408\u9ad4<\/strong><strong> I <\/strong><strong>\u6d3b\u6027\u4e0b\u964d<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300cATP\/ADP \u6301\u7e8c\u4f4e\u6bd4\u503c\uff08&lt;1.5\uff09\uff1b\u524d\u984d\u8449\u76ae\u5c64\u7dda\u7c92\u9ad4\u8907\u5408\u9ad4 I \u6d3b\u6027\u4e0b\u964d 40%\uff08J Clin Invest. 2024\uff09\u300d\u3002<\/p>\n\n\n\n<p>\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u78ba\u5be6\u88ab\u8a8d\u70ba\u662f\u91cd\u5ea6\u6291\u9b31\u75c7\u7684\u95dc\u9375\u75c5\u7406\u751f\u7406\u5b78\u56e0\u7d20\u4e4b\u4e00\uff0c\u5c0e\u81f4ATP\u751f\u6210\u6e1b\u5c11 <sup>4<\/sup>\u3002\u6291\u9b31\u75c7\u60a3\u8005\u7684ATP\u548cADP\u6c34\u5e73\u7570\u5e38\u5df2\u88ab\u591a\u9805\u81e8\u5e8a\u548c\u81e8\u5e8a\u524d\u7814\u7a76\u89c0\u5bdf\u5230 <sup>6<\/sup>\u3002\u524d\u984d\u8449\u76ae\u5c64 (PFC) \u4f5c\u70ba\u8207\u6291\u9b31\u75c7\u6700\u5bc6\u5207\u76f8\u95dc\u7684\u8166\u5340\u4e4b\u4e00\uff0c\u5176\u529f\u80fd\u548c\u7d50\u69cb\u7570\u5e38\u5728MDD\u60a3\u8005\u4e2d\u6301\u7e8c\u5b58\u5728 <sup>7<\/sup>\u3002\u8ca0\u9762\u60c5\u7dd2\u8207\u80cc\u5916\u5074\u524d\u984d\u8449\u76ae\u5c64 (DLPFC) \u4e2d\u7dda\u7c92\u9ad4\u6c27\u5316\u78f7\u9178\u5316 (OxPhos) \u6a5f\u5668\uff08\u5305\u62ec\u8907\u5408\u9ad4I\uff09\u7684\u8c50\u5ea6\u964d\u4f4e\u76f8\u95dc\u3002\u7814\u7a76\u6307\u51fa\uff0c\u6b63\u5411\u548c\u8ca0\u5411\u7684\u5fc3\u7406\u793e\u6703\u56e0\u7d20\u53ef\u89e3\u91cbDLPFC\u4e2dOxPhos\u8907\u5408\u9ad4I\u8c50\u5ea6\u8b8a\u7570\u768418%\u81f325% <sup>8<\/sup>\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u95dc\u65bc\u300cATP\/ADP \u6301\u7e8c\u4f4e\u6bd4\u503c\uff08&lt;1.5\uff09\u300d\u6216\u300c\u524d\u984d\u8449\u76ae\u5c64\u7dda\u7c92\u9ad4\u8907\u5408\u9ad4 I \u6d3b\u6027\u4e0b\u964d 40%\u300d\u7684\u5177\u9ad4\u91cf\u5316\u6578\u64da\uff0c\u5728\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599\u4e2d\u4e26\u672a\u76f4\u63a5\u627e\u5230\u652f\u6301\u3002\u6b64\u5916\uff0c\u300cJ Clin Invest. 2024\u300d\u662f\u4e00\u500b\u672a\u4f86\u5e74\u4efd\u7684\u5f15\u7528\uff0c\u7121\u6cd5\u7528\u65bc\u9a57\u8b49\u5df2\u767c\u8868\u7684\u5be6\u8b49\u6578\u64da\u3002\u56e0\u6b64\uff0c\u61c9\u4fee\u6b63\u70ba\uff1a\u7dda\u7c92\u9ad4\u8907\u5408\u9ad4I\u529f\u80fd\u969c\u7919\u5728\u524d\u984d\u8449\u76ae\u5c64\u4e2d\u8207\u6291\u9b31\u75c7\u9ad8\u5ea6\u76f8\u95dc\uff0c\u5c0e\u81f4ATP\u751f\u6210\u986f\u8457\u6e1b\u5c11\uff0c\u9032\u800c\u53ef\u80fd\u5c0e\u81f4ATP\/ADP\u6bd4\u503c\u6301\u7e8c\u504f\u4f4e\u3002\u5118\u7ba1\u7dda\u7c92\u9ad4\u529f\u80fd\u53d7\u640d\u662f\u6838\u5fc3\u75c5\u7406\uff0c\u4f46\u6a21\u578b\u4e2d\u63d0\u51fa\u7684\u5177\u9ad4\u4e0b\u964d\u767e\u5206\u6bd4\u548c\u6bd4\u503c\u95be\u503c\uff0c\u4ecd\u9700\u66f4\u591a\u76f4\u63a5\u4e14\u5df2\u767c\u8868\u7684\u5be6\u8b49\u6578\u64da\u652f\u6301\u3002<\/p>\n\n\n\n<p><strong>\u817a\u82f7\u7570\u5e38\u7d2f\u7a4d<\/strong><strong> \u2192 <\/strong><strong>\u904e\u5ea6\u555f\u52d5<\/strong><strong> A2A <\/strong><strong>\u53d7\u9ad4<\/strong><strong> \u2192 <\/strong><strong>\u8a98\u767c\u75c5\u7406\u6027\u7126\u616e<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u817a\u82f7\u7570\u5e38\u7d2f\u7a4d \u2192 \u904e\u5ea6\u555f\u52d5 A2A \u53d7\u9ad4 \u2192 \u8a98\u767c\u75c5\u7406\u6027\u7126\u616e\uff08\u975e\u751f\u7406\u6027\u7761\u7720\u58d3\u529b\uff09\u300d\u3002<\/p>\n\n\n\n<p>\u817a\u82f7A2A\u53d7\u9ad4 (A2AR) \u5728\u57fa\u5e95\u795e\u7d93\u7bc0\u4e2d\u9ad8\u5ea6\u8868\u9054\uff0c\u4e26\u88ab\u8b49\u5be6\u53c3\u8207\u7126\u616e\u7684\u8abf\u7bc0 <sup>9<\/sup>\u3002\u52d5\u7269\u6a21\u578b\u7814\u7a76\u986f\u793a\uff0c\u5927\u8166\u524d\u984d\u8449\uff08\u5305\u62ec\u6d77\u99ac\u548c\u76ae\u5c64\uff09A2AR\u7684\u904e\u5ea6\u8868\u9054\u53ef\u5c0e\u81f4\u6291\u9b31\u6a23\u884c\u70ba\u3001\u6d3b\u52d5\u904e\u5ea6\u548c\u63a2\u7d22\u884c\u70ba\u6539\u8b8a <sup>9<\/sup>\u3002A2AR\u7684\u904e\u5ea6\u6d3b\u5316\u4e5f\u8207\u8870\u8001\u548c\u6162\u6027\u58d3\u529b\u76f8\u95dc <sup>9<\/sup>\u3002\u6b64\u5916\uff0c\u817a\u82f7\u53ef\u900f\u904e\u6d3b\u5316 caspase-1 \u548c\u589e\u52a0\u8166\u5167\u767d\u4ecb\u7d20-1\u03b2 (IL-1\u03b2) \u4f86\u8a98\u767c\u7126\u616e\u6a23\u884c\u70ba\uff0c\u6b64\u904e\u7a0b\u4f9d\u8cf4\u65bcA2AR <sup>11<\/sup>\u3002\u9019\u8868\u660e\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u5c0e\u81f4\u7684ATP\u5206\u89e3\u7522\u7269\u817a\u82f7\u7684\u7570\u5e38\u7d2f\u7a4d\uff0c\u53ef\u80fd\u900f\u904eA2AR\u4ecb\u5c0e\u7684\u4fe1\u865f\u901a\u8def\uff0c\u4fc3\u9032\u4fc3\u708e\u7d30\u80de\u56e0\u5b50\u7684\u91cb\u653e\uff0c\u9032\u800c\u8a98\u767c\u75c5\u7406\u6027\u7126\u616e\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0cA2AR\u7684\u89d2\u8272\u53ef\u80fd\u66f4\u70ba\u8907\u96dc\u3002\u4f8b\u5982\uff0c\u6709\u7814\u7a76\u6307\u51faA2AR\u523a\u6fc0\u80fd\u589e\u5f37\u7dda\u7c92\u9ad4\u4ee3\u8b1d\u4e26\u6e1b\u8f15\u6d3b\u6027\u6c27\u4ecb\u5c0e\u7684\u7dda\u7c92\u9ad4\u640d\u50b7\uff0c\u63d0\u793aA2AR\u53ef\u80fd\u5177\u6709\u7dda\u7c92\u9ad4\u4fdd\u8b77\u4f5c\u7528 <sup>12<\/sup>\u3002\u9019\u8aaa\u660e\u817a\u82f7-A2AR\u8ef8\u5728\u4e0d\u540c\u751f\u7406\u548c\u75c5\u7406\u689d\u4ef6\u4e0b\u7684\u4f5c\u7528\u53ef\u80fd\u5b58\u5728\u96d9\u5411\u6027\u3002\u6a21\u578b\u4e2d\u300c\u975e\u751f\u7406\u6027\u7761\u7720\u58d3\u529b\u300d\u7684\u63cf\u8ff0\uff0c\u5728\u6240\u63d0\u4f9b\u7684\u8cc7\u6599\u4e2d\u672a\u898b\u76f4\u63a5\u95e1\u8ff0\u3002\u56e0\u6b64\uff0c\u61c9\u4fee\u6b63\u70ba\uff1a\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u53ef\u80fd\u5c0e\u81f4\u817a\u82f7\u7570\u5e38\u7d2f\u7a4d\uff0c\u9032\u800c\u904e\u5ea6\u6d3b\u5316A2A\u53d7\u9ad4\uff0c\u6b64\u904e\u5ea6\u6d3b\u5316\u8207\u7126\u616e\u6a23\u884c\u70ba\u76f8\u95dc\uff0c\u4e26\u53ef\u80fd\u6d89\u53ca\u4fc3\u708e\u7d30\u80de\u56e0\u5b50\u7684\u91cb\u653e\u3002A2AR\u5728\u7dda\u7c92\u9ad4\u529f\u80fd\u548c\u708e\u75c7\u53cd\u61c9\u4e2d\u7684\u8907\u96dc\u4f5c\u7528\uff0c\u63d0\u793a\u5176\u5728\u7126\u616e\u75c5\u7406\u4e2d\u7684\u7cbe\u78ba\u6a5f\u5236\u4ecd\u9700\u6df1\u5165\u7814\u7a76\u3002<\/p>\n\n\n\n<p><strong>GABA<\/strong><strong>\u80fd\u7cfb\u7d71\u7f3a\u9677<\/strong><strong><\/strong><\/p>\n\n\n\n<p>GABA\uff08\u03b3-\u6c28\u57fa\u4e01\u9178\uff09\u662f\u54fa\u4e73\u52d5\u7269\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u4e2d\u4e3b\u8981\u7684\u6291\u5236\u6027\u795e\u7d93\u905e\u8cea\uff0c\u5c0d\u65bc\u7dad\u6301\u795e\u7d93\u5143\u8208\u596e\u8207\u6291\u5236\u7684\u5e73\u8861\u81f3\u95dc\u91cd\u8981 <sup>1<\/sup>\u3002<\/p>\n\n\n\n<p><strong>\u6291\u9b31\u60a3\u8005\u6d77\u99ac\u5340<\/strong><strong> GABAA <\/strong><strong>\u53d7\u9ad4<\/strong><strong> \u03b15 <\/strong><strong>\u4e9e\u57fa\u8868\u9054\u6e1b\u5c11<\/strong><strong> 60%<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u6291\u9b31\u60a3\u8005\u6d77\u99ac\u5340 GABAA \u53d7\u9ad4 \u03b15 \u4e9e\u57fa\u8868\u9054\u6e1b\u5c11 60%\uff08Nat Neurosci. 2025\uff09\u300d\u3002<\/p>\n\n\n\n<p>\u91cd\u5ea6\u6291\u9b31\u75c7\u60a3\u8005\u8166\u5167GABA\u6fc3\u5ea6\u964d\u4f4e\uff0c\u4ee5\u53caGABAA\u53d7\u9ad4\u4e9e\u57fa\u7d44\u6210\u7684\u6539\u8b8a\uff0c\u88ab\u8a8d\u70ba\u662f\u6291\u9b31\u75c7\u75c5\u56e0\u7684\u6838\u5fc3\u548c\u539f\u56e0 <sup>16<\/sup>\u3002GABAA\u53d7\u9ad4\u03b15\u4e9e\u57fa\u5728\u6d77\u99ac\u9ad4\u4e2d\u8c50\u5bcc\u8868\u9054\uff0c\u4e3b\u8981\u4ecb\u5c0e\u5f35\u529b\u6027\u6291\u5236\uff0c\u4e26\u5728\u7a81\u89f8\u53ef\u5851\u6027\u548c\u6d77\u99ac\u4f9d\u8cf4\u6027\u8a18\u61b6\u4e2d\u626e\u6f14\u95dc\u9375\u89d2\u8272 <sup>13<\/sup>\u3002\u5c0d\u03b15\u4e9e\u57fa\u7684\u963b\u65b7\u5df2\u88ab\u8b49\u660e\u80fd\u6539\u5584\u6d77\u99ac\u4f9d\u8cf4\u6027\u8a18\u61b6 <sup>18<\/sup>\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u539f\u59cb\u6a21\u578b\u4e2d\u95dc\u65bcGABAA \u03b15\u4e9e\u57fa\u5728\u6291\u9b31\u60a3\u8005\u6d77\u99ac\u5340\u300c\u6e1b\u5c1160%\u300d\u7684\u8072\u7a31\u8207\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599<strong>\u76f4\u63a5\u77db\u76fe<\/strong>\u3002\u4e8b\u5be6\u4e0a\uff0c\u6709\u7814\u7a76\u986f\u793a\uff0c\u5728\u96d9\u5411\u60c5\u611f\u969c\u7919 (BPD) \u60a3\u8005\u7684\u67d0\u4e9b\u8166\u5340\uff08\u5982Brodmann 9, 24, 46 \u5340\uff09\u4ee5\u53ca\u6291\u9b31\u81ea\u6bba\u8005 (Depressed suicides) \u7684\u67d0\u4e9b\u8166\u5340\uff08\u5982Brodmann 20, 46 \u5340\uff09\uff0cGABAA \u03b15 \u4e9e\u57fa\u7684\u8868\u9054\u662f\u300c\u4e0a\u8abf\u300d\u7684\uff0c\u800c\u975e\u6e1b\u5c11 <sup>16<\/sup>\u3002\u6b64\u5916\uff0c\u300cNat Neurosci. 2025\u300d\u70ba\u672a\u4f86\u5e74\u4efd\u7684\u5f15\u7528\uff0c\u7121\u6cd5\u9a57\u8b49\u3002\u56e0\u6b64\uff0c\u61c9\u4fee\u6b63\u70ba\uff1a\u6291\u9b31\u75c7\u60a3\u8005\u7684GABA\u80fd\u7cfb\u7d71\u78ba\u5be6\u5b58\u5728\u7f3a\u9677\uff0c\u4f46GABAA\u53d7\u9ad4\u03b15\u4e9e\u57fa\u7684\u8868\u9054\u8b8a\u5316\u662f\u8907\u96dc\u4e14\u60c5\u5883\u4f9d\u8cf4\u7684\uff0c\u53ef\u80fd\u5728\u67d0\u4e9b\u8166\u5340\u8868\u73fe\u70ba\u4e0a\u8abf\uff0c\u800c\u975e\u666e\u904d\u7684\u6e1b\u5c11\u3002\u5176\u5728\u6d77\u99ac\u9ad4\u4e2d\u5c0d\u8a18\u61b6\u548c\u7126\u616e\u7684\u5177\u9ad4\u5f71\u97ff\uff0c\u63d0\u793a\u5176\u5728\u75c5\u7406\u6a5f\u5236\u4e2d\u7684\u7cbe\u78ba\u89d2\u8272\u4ecd\u9700\u9032\u4e00\u6b65\u95e1\u660e\u3002<\/p>\n\n\n\n<p><strong>\u7126\u616e\u6a21\u578b\u52d5\u7269<\/strong><strong> GAD67 <\/strong><strong>\u9176\u6d3b\u6027\u4e0b\u964d<\/strong><strong> \u2192 GABA <\/strong><strong>\u5408\u6210\u4e0d\u8db3<\/strong><strong> \u2192 <\/strong><strong>\u674f\u4ec1\u6838\u904e\u5ea6\u8208\u596e<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u7126\u616e\u6a21\u578b\u52d5\u7269 GAD67 \u9176\u6d3b\u6027\u4e0b\u964d \u2192 GABA \u5408\u6210\u4e0d\u8db3 \u2192 \u674f\u4ec1\u6838\u904e\u5ea6\u8208\u596e\u300d\u3002<\/p>\n\n\n\n<p>GABA\u662f\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u4e2d\u7d04\u4e09\u5206\u4e4b\u4e00\u795e\u7d93\u5143\u7684\u4e3b\u8981\u6291\u5236\u6027\u795e\u7d93\u905e\u8cea <sup>14<\/sup>\u3002\u674f\u4ec1\u6838\u4f5c\u70ba\u60c5\u7dd2\u8655\u7406\u7684\u6838\u5fc3\u8166\u5340\uff0c\u5176GABA\u80fd\u50b3\u905e\u5c0d\u65bc\u60c5\u7dd2\u8655\u7406\u81f3\u95dc\u91cd\u8981 <sup>1<\/sup>\u3002\u674f\u4ec1\u6838GABA\u80fd\u6291\u5236\u7684\u7834\u58de\u5df2\u88ab\u8b49\u5be6\u53ef\u5c0e\u81f4\u884c\u70ba\u904e\u5ea6\u8208\u596e\u3001\u7126\u616e\u548c\u6291\u9b31\u7b49\u60c5\u7dd2\u5931\u8abf <sup>14<\/sup>\u3002GAD67\uff08\u8c37\u6c28\u9178\u812b\u7fa7\u917667\uff09\u8ca0\u8cac\u5408\u6210\u8166\u4e2d\u8d85\u904e90%\u7684\u57fa\u790eGABA\u6c34\u5e73\uff0c\u5c0d\u65bc\u7dad\u6301\u57fa\u790eGABA\u6fc3\u5ea6\u81f3\u95dc\u91cd\u8981 <sup>15<\/sup>\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u539f\u59cb\u6a21\u578b\u4e2d\u95dc\u65bc\u300c\u7126\u616e\u6a21\u578b\u52d5\u7269 GAD67 \u9176\u6d3b\u6027\u4e0b\u964d\u300d\u7684\u8072\u7a31\u8207\u6240\u63d0\u4f9b\u7684\u8b49\u64da<strong>\u76f4\u63a5\u53cd\u99c1<\/strong>\u3002\u7814\u7a76\u767c\u73fe\uff0c\u5177\u6709\u9ad8\u7126\u616e\u884c\u70ba\u7684\u5c0f\u9f20\uff0c\u5176\u674f\u4ec1\u6838\u4e2d\u7684GABA\u6c34\u5e73\u548cGABA\u901a\u8def\u7d44\u5206GAD65\u548cGAD67\u7684\u8868\u9054\u6c34\u5e73\u5be6\u969b\u4e0a\u9ad8\u65bc\u5177\u6709\u6b63\u5e38\u7126\u616e\u884c\u70ba\u7684\u5c0f\u9f20 <sup>1<\/sup>\u3002\u9019\u8868\u660e\u7126\u616e\u53ef\u80fd\u8207GABA\u80fd\u7cfb\u7d71\u7684\u8907\u96dc\u5931\u8abf\u6709\u95dc\uff0c\u800c\u975e\u7c21\u55ae\u7684GABA\u5408\u6210\u4e0d\u8db3\u3002\u674f\u4ec1\u6838\u7684\u904e\u5ea6\u8208\u596e\u78ba\u5be6\u8207GABA\u80fd\u6291\u5236\u7684\u7834\u58de\u76f8\u95dc <sup>14<\/sup>\uff0c\u9019\u53ef\u80fd\u6e90\u65bcGABA\u91cb\u653e\u6216\u53d7\u9ad4\u529f\u80fd\u7684\u7570\u5e38\uff0c\u800c\u975e\u5408\u6210\u9176\u6d3b\u6027\u7684\u666e\u904d\u4e0b\u964d\u3002GAD67\u7f3a\u9677\u5c0f\u9f20\u5728\u570d\u7522\u671f\u8868\u73fe\u51fa\u81f4\u6b7b\u6027\u8868\u578b\uff0c\u51fa\u751f\u6642GABA\u6c34\u5e73\u50c5\u70ba\u91ce\u751f\u578b\u76847% <sup>21<\/sup>\uff0c\u9019\u4e5f\u5f37\u8abf\u4e86GAD67\u5728\u7dad\u6301\u57fa\u790eGABA\u6c34\u5e73\u65b9\u9762\u7684\u95dc\u9375\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u61c9\u4fee\u6b63\u70ba\uff1a\u7126\u616e\u75c7\u53ef\u80fd\u6d89\u53caGABA\u80fd\u7cfb\u7d71\u7684\u8907\u96dc\u5931\u8abf\uff0c\u800c\u975e\u55ae\u7d14\u7684GAD67\u9176\u6d3b\u6027\u4e0b\u964d\u5c0e\u81f4GABA\u5408\u6210\u4e0d\u8db3\u3002\u90e8\u5206\u7814\u7a76\u986f\u793a\uff0c\u9ad8\u7126\u616e\u884c\u70ba\u53ef\u80fd\u4f34\u96a8\u674f\u4ec1\u6838GABA\u6c34\u5e73\u548cGAD67\/65\u8868\u9054\u7684\u5347\u9ad8\uff0c\u63d0\u793aGABA\u80fd\u50b3\u905e\u7684\u52d5\u614b\u5e73\u8861\u6216\u91cb\u653e\u6a5f\u5236\u53ef\u80fd\u53d7\u640d\uff0c\u9032\u800c\u5c0e\u81f4\u674f\u4ec1\u6838\u904e\u5ea6\u8208\u596e\u3002<\/p>\n\n\n\n<p><strong>\u795e\u7d93\u708e\u75c7<\/strong><strong>&#8211;<\/strong><strong>\u7dda\u7c92\u9ad4\u60e1\u6027\u5faa\u74b0<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u63d0\u51fa\uff1a\u300c\u58d3\u529b[\u6162\u6027\u58d3\u529b] &#8211;&gt; \u76ae\u8cea\u9187\u2191 &#8211;&gt; NF-\u03baB\u555f\u52d5 &#8211;&gt; TNF-\u03b1\/IL-6\u2191\uff1bTNF-\u03b1\/IL-6\u2191 &#8211;&gt; \u640d\u50b7\u7dda\u7c92\u9ad4DNA &#8211;&gt; ATP\u2193 &#8211;&gt; \u795e\u7d93\u5143\u51cb\u4ea1 &#8211;&gt; \u6291\u9b31\u884c\u70ba\u300d\u3002<\/p>\n\n\n\n<p>\u6162\u6027\u58d3\u529b\u662f\u795e\u7d93\u708e\u75c7\u548c\u6291\u9b31\u75c7\u7684\u91cd\u8981\u75c5\u56e0\u98a8\u96aa\u56e0\u7d20 <sup>3<\/sup>\u3002\u58d3\u529b\u53ef\u5c0e\u81f4\u4e0b\u4e18\u8166-\u5782\u9ad4-\u814e\u4e0a\u817a (HPA) \u8ef8\u529f\u80fd\u7d0a\u4e82\u548c\u514d\u75ab\u7d30\u80de\u7cd6\u76ae\u8cea\u6fc0\u7d20\u62b5\u6297\uff0c\u9032\u800c\u5f15\u8d77\u5916\u5468\u514d\u75ab\u7cfb\u7d71\u7684\u904e\u5ea6\u6d3b\u5316 <sup>3<\/sup>\u3002\u6162\u6027\u61c9\u6fc0\u66b4\u9732\u6703\u589e\u52a0\u4fc3\u708e\u7d30\u80de\u56e0\u5b50\uff08\u5982IL-1\u03b2\u3001IL-6\u548cTNF-\u03b1\uff09\u7684\u6c34\u5e73\uff0c\u9019\u4e9b\u7d30\u80de\u56e0\u5b50\u8207\u6291\u9b31\u75c7\u72c0\u7684\u56b4\u91cd\u7a0b\u5ea6\u5448\u6b63\u76f8\u95dc <sup>3<\/sup>\u3002\u4f8b\u5982\uff0c\u5728\u6613\u611f\u52d5\u7269\u6a21\u578b\u4e2d\uff0cIL-6\u7684\u6c34\u5e73\u53ef\u6bd4\u62b5\u6297\u7d44\u9ad8\u51fa27\u500d <sup>3<\/sup>\u3002<\/p>\n\n\n\n<p>\u9019\u4e9b\u4fc3\u708e\u7d30\u80de\u56e0\u5b50\u8207\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u4e4b\u9593\u5b58\u5728\u5bc6\u5207\u95dc\u806f\uff0c\u5f62\u6210\u4e00\u500b\u60e1\u6027\u5faa\u74b0\u3002NF-\u03baB\u662f\u708e\u75c7\u53cd\u61c9\u7684\u95dc\u9375\u8f49\u9304\u56e0\u5b50\uff0c\u5176\u6d3b\u5316\u53ef\u5c0e\u81f4\u4fc3\u708e\u7d30\u80de\u56e0\u5b50\u7684\u7522\u751f\u3002\u7814\u7a76\u8868\u660e\uff0c\u5728\u708e\u75c7\u904e\u7a0b\u4e2d\uff0cNF-\u03baB\u6703\u964d\u4f4ePGC-1\u03b1\u7684\u8868\u9054\u548c\u6d3b\u6027\uff0c\u800cPGC-1\u03b1\u662f\u7dda\u7c92\u9ad4\u751f\u7269\u5408\u6210\u548c\u529f\u80fd\u7684\u4e3b\u8981\u8abf\u7bc0\u56e0\u5b50 <sup>24<\/sup>\u3002PGC-1\u03b1\u6d3b\u6027\u964d\u4f4e\u6703\u5c0e\u81f4\u6297\u6c27\u5316\u57fa\u56e0\u4e0b\u8abf\uff0c\u9032\u800c\u52a0\u5287\u6c27\u5316\u61c9\u6fc0 <sup>24<\/sup>\u3002\u7dda\u7c92\u9ad4\u4f5c\u70ba\u7d30\u80de\u7684\u80fd\u91cf\u4e2d\u5fc3\uff0c\u5176\u529f\u80fd\u53d7\u640d\u6703\u5c0e\u81f4ATP\u751f\u6210\u6e1b\u5c11\uff0c\u4e26\u589e\u52a0\u6d3b\u6027\u6c27 (ROS) \u7684\u7522\u751f\uff0c\u9032\u800c\u640d\u5bb3\u7dda\u7c92\u9ad4DNA (mtDNA) \u548c\u5176\u4ed6\u7d30\u80de\u7d50\u69cb <sup>4<\/sup>\u3002mtDNA \u7de8\u78bc\u96fb\u5b50\u50b3\u8f38\u93c8\u768413\u500b\u591a\u80bd\uff0c\u5176\u640d\u50b7\u53ef\u80fd\u6539\u8b8a\u96fb\u5b50\u50b3\u8f38\u8907\u5408\u9ad4\uff0c\u5c0e\u81f4ATP\u751f\u6210\u4e0b\u964d\u4e26\u7522\u751f\u66f4\u591aROS <sup>25<\/sup>\u3002\u9577\u671f\u7684\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u3001\u6c27\u5316\u61c9\u6fc0\u548c\u795e\u7d93\u708e\u75c7\u6700\u7d42\u6703\u5c0e\u81f4\u795e\u7d93\u5143\u51cb\u4ea1\u548c\u795e\u7d93\u53ef\u5851\u6027\u53d7\u640d\uff0c\u9019\u4e9b\u90fd\u662f\u6291\u9b31\u884c\u70ba\u7684\u751f\u7269\u5b78\u57fa\u790e <sup>4<\/sup>\u3002<\/p>\n\n\n\n<p>\u56e0\u6b64\uff0c\u539f\u59cb\u6a21\u578b\u4e2d\u63cf\u8ff0\u7684\u58d3\u529b-\u76ae\u8cea\u9187-\u708e\u75c7-\u7dda\u7c92\u9ad4\u640d\u50b7-\u795e\u7d93\u5143\u51cb\u4ea1-\u6291\u9b31\u7684\u60e1\u6027\u5faa\u74b0\uff0c\u5728\u6982\u5ff5\u4e0a\u8207\u73fe\u6709\u79d1\u5b78\u8b49\u64da\u9ad8\u5ea6\u4e00\u81f4\uff0c\u4e26\u5f37\u8abf\u4e86\u795e\u7d93\u708e\u75c7\u8207\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u5728\u6291\u9b31\u75c5\u7406\u4e2d\u7684\u6838\u5fc3\u4f5c\u7528\u3002<\/p>\n\n\n\n<p><strong>\u7b2c\u4e8c\u7ae0\uff1a\u4e2d\u85e5\u6cbb\u7642\u7684\u8eab\u5fc3\u6574\u5408\u6a5f\u5236<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u4e2d\u91ab\u85e5\u5728\u8abf\u7bc0\u8907\u96dc\u7684\u751f\u7269\u7db2\u7d61\u65b9\u9762\u5177\u6709\u7368\u7279\u512a\u52e2\uff0c\u5176\u591a\u9776\u9ede\u3001\u591a\u5c64\u6b21\u7684\u5e72\u9810\u7b56\u7565\u8207\u73fe\u4ee3\u91ab\u5b78\u5c0d\u7126\u616e\u6291\u9b31\u75c7\u7684\u7cfb\u7d71\u6027\u7406\u89e3\u76f8\u5951\u5408\u3002<\/p>\n\n\n\n<p><strong>\u6838\u5fc3\u65b9\u5291\u64f4\u5c55\u8207\u85e5\u6750\u65b0\u589e\u9776\u9ede\u5206\u5b50\u8b49\u64da<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>\u9178\u68d7\u4ec1\u4e0a\u8abf<\/strong><strong> GABAA \u03b15 <\/strong><strong>\u4e9e\u57fa\u589e\u5f37\u6d77\u99ac\u6291\u5236\u6027\u7a81\u89f8\u50b3\u905e<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u9178\u68d7\u4ec1\u4e0a\u8abf GABAA \u03b15 \u4e9e\u57fa\u589e\u5f37\u6d77\u99ac\u6291\u5236\u6027\u7a81\u89f8\u50b3\u905e\uff08eLife. 2025\uff09\u300d\u3002<\/p>\n\n\n\n<p>\u9178\u68d7\u4ec1\uff08Ziziphus jujuba Mill.\uff09\u4f5c\u70ba\u50b3\u7d71\u4e2d\u85e5\uff0c\u5177\u6709\u986f\u8457\u7684\u93ae\u975c\u3001\u5b89\u7720\u548c\u6297\u7126\u616e\u4f5c\u7528 <sup>26<\/sup>\u3002\u7814\u7a76\u986f\u793a\uff0c\u9178\u68d7\u4ec1\u63d0\u53d6\u7269\u80fd\u986f\u8457\u4e0a\u8abf\u4eba\u795e\u7d93\u6bcd\u7d30\u80de\u7624SH-SY5Y\u7d30\u80de\u4e2dGABAA\u53d7\u9ad4\u03b11\u548c\u03b13\u4e9e\u57fa\u7684mRNA\u6c34\u5e73\uff0c\u4e26\u96d9\u5411\u8abf\u7bc0GABA\u80fd\u548c\u8840\u6e05\u7d20\u80fd\u7a81\u89f8\u901a\u8def <sup>26<\/sup>\u3002GABAA\u53d7\u9ad4\u03b15\u4e9e\u57fa\u5728\u6d77\u99ac\u9ad4\u4e2d\u9ad8\u5ea6\u8868\u9054\uff0c\u53c3\u8207\u8abf\u7bc0\u7a81\u89f8\u53ef\u5851\u6027\u3001\u8a8d\u77e5\u548c\u8a18\u61b6 <sup>13<\/sup>\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599\u76f4\u63a5\u652f\u6301\u9178\u68d7\u4ec1\u4e0a\u8abf\u7684\u662fGABRA1\u548cGABRA3\uff0c\u800c\u975e\u7279\u7570\u6027\u5730GABAA \u03b15\u4e9e\u57fa\u3002\u6b64\u5916\uff0c\u9019\u4e9b\u8b49\u64da\u4e3b\u8981\u4f86\u81ea\u9ad4\u5916\u7d30\u80de\u5be6\u9a57\uff0c\u7f3a\u4e4f\u76f4\u63a5\u7684\u9ad4\u5167\uff08\u7279\u5225\u662f\u6d77\u99ac\u5340\uff09\u4e0a\u8abf\u03b15\u4e9e\u57fa\u4e26\u589e\u5f37\u6291\u5236\u6027\u7a81\u89f8\u50b3\u905e\u7684\u8b49\u64da\u3002\u539f\u59cb\u6a21\u578b\u4e2d\u5f15\u7528\u7684\u300ceLife. 2025\u300d\u70ba\u672a\u4f86\u5e74\u4efd\u7684\u6587\u737b\uff0c\u7121\u6cd5\u9a57\u8b49\u3002\u56e0\u6b64\uff0c\u61c9\u4fee\u6b63\u70ba\uff1a\u9178\u68d7\u4ec1\u900f\u904e\u8abf\u7bc0GABA\u80fd\u548c\u8840\u6e05\u7d20\u80fd\u7a81\u89f8\u901a\u8def\u767c\u63ee\u6297\u7126\u616e\u4f5c\u7528\uff0c\u9ad4\u5916\u7814\u7a76\u986f\u793a\u5176\u80fd\u4e0a\u8abfGABAA\u53d7\u9ad4\u03b11\u548c\u03b13\u4e9e\u57fa\u7684\u8868\u9054\u3002\u5118\u7ba1GABAA \u03b15\u4e9e\u57fa\u5728\u6d77\u99ac\u9ad4\u4e2d\u5c0d\u60c5\u7dd2\u548c\u8a8d\u77e5\u529f\u80fd\u6709\u91cd\u8981\u5f71\u97ff\uff0c\u4f46\u9178\u68d7\u4ec1\u662f\u5426\u7279\u7570\u6027\u4e0a\u8abf\u03b15\u4e9e\u57fa\u4e26\u589e\u5f37\u6d77\u99ac\u6291\u5236\u6027\u7a81\u89f8\u50b3\u905e\uff0c\u4ecd\u9700\u9032\u4e00\u6b65\u7684\u9ad4\u5167\u7814\u7a76\u8b49\u5be6\u3002<\/p>\n\n\n\n<p><strong>\u67f4\u80e1\u6291\u5236<\/strong><strong> IDO <\/strong><strong>\u9176\u6e1b\u5c11\u72ac\u5c3f\u6c28\u9178<\/strong><strong>\u2192<\/strong><strong>\u55b9\u5549\u9178\u795e\u7d93\u6bd2\u7d20<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u67f4\u80e1\u6291\u5236 IDO \u9176\u6e1b\u5c11\u72ac\u5c3f\u6c28\u9178\u2192\u55b9\u5549\u9178\u795e\u7d93\u6bd2\u7d20\uff08Cell. 2024\uff09\u300d\u3002<\/p>\n\n\n\n<p>\u72ac\u5c3f\u6c28\u9178\u901a\u8def (KP) \u662f\u8272\u6c28\u9178\u4ee3\u8b1d\u7684\u4e3b\u8981\u9014\u5f91\uff0c\u5176\u4e0b\u6e38\u4ee3\u8b1d\u7522\u7269\u53c3\u8207\u591a\u7a2e\u751f\u7406\u548c\u75c5\u7406\u904e\u7a0b <sup>28<\/sup>\u3002\u5432\u54da\u80fa2,3-\u96d9\u52a0\u6c27\u9176 (IDO) \u662fKP\u7684\u8d77\u59cb\u548c\u95dc\u9375\u9176\uff0c\u5176\u6d3b\u6027\u8207\u708e\u75c7\u548c\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u76f8\u95dc <sup>28<\/sup>\u3002\u55b9\u5549\u9178 (QUIN) \u662fKP\u7684\u4e0b\u6e38\u4ee3\u8b1d\u7522\u7269\uff0c\u7531\u6d3b\u5316\u7684\u5c0f\u81a0\u8cea\u7d30\u80de\u7522\u751f\uff0c\u4f5c\u70baNMDA\u53d7\u9ad4\u6fc0\u52d5\u5291\uff0c\u904e\u5ea6\u523a\u6fc0\u53ef\u5c0e\u81f4\u8208\u596e\u6027\u6bd2\u6027\u548c\u795e\u7d93\u5143\u6b7b\u4ea1 <sup>29<\/sup>\u3002\u67f4\u80e1\uff08Bupleurum chinense\uff09\u4f5c\u70ba\u50b3\u7d71\u4e2d\u85e5\uff0c\u5177\u6709\u6297\u708e\u548c\u758f\u809d\u89e3\u9b31\u7684\u529f\u6548\uff0c\u7528\u65bc\u6539\u5584\u60c5\u7dd2\u4e0d\u7a69\u5982\u6291\u9b31\u548c\u7126\u616e <sup>32<\/sup>\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u5728\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599\u4e2d\uff0c<strong>\u6c92\u6709\u76f4\u63a5\u8b49\u64da\u8868\u660e\u67f4\u80e1\u80fd\u5920\u6291\u5236<\/strong><strong>IDO<\/strong><strong>\u9176\u6216\u76f4\u63a5\u6e1b\u5c11\u72ac\u5c3f\u6c28\u9178\u548c\u55b9\u5549\u9178\u7684\u7522\u751f<\/strong>\u3002\u96d6\u7136\u67f4\u80e1\u5177\u6709\u6297\u708e\u4f5c\u7528\uff08\u4f8b\u5982\u964d\u4f4eTNF-\u03b1 <sup>32<\/sup>\uff09\uff0c\u4e14IDO\u901a\u8def\u8207\u708e\u75c7\u548c\u795e\u7d93\u6bd2\u6027\u76f8\u95dc\uff0c\u4f46\u9019\u4e26\u4e0d\u69cb\u6210\u67f4\u80e1\u76f4\u63a5\u6291\u5236IDO\u7684\u8b49\u64da\u93c8\u3002\u539f\u59cb\u6a21\u578b\u4e2d\u5f15\u7528\u7684\u300cCell. 2024\u300d\u70ba\u672a\u4f86\u5e74\u4efd\u7684\u6587\u737b\uff0c\u7121\u6cd5\u9a57\u8b49\u3002\u56e0\u6b64\uff0c\u61c9\u4fee\u6b63\u70ba\uff1a\u67f4\u80e1\u5177\u6709\u6297\u708e\u548c\u6539\u5584\u60c5\u7dd2\u7684\u6f5b\u529b\uff0c\u4f46\u5176\u662f\u5426\u900f\u904e\u76f4\u63a5\u6291\u5236IDO\u9176\u4f86\u6e1b\u5c11\u72ac\u5c3f\u6c28\u9178\u548c\u55b9\u5549\u9178\u7b49\u795e\u7d93\u6bd2\u7d20\u7684\u7522\u751f\uff0c\u76ee\u524d\u5728\u73fe\u6709\u8b49\u64da\u4e2d\u7f3a\u4e4f\u76f4\u63a5\u652f\u6301\uff0c\u9019\u4ecd\u662f\u4e00\u500b\u503c\u5f97\u63a2\u7d22\u7684\u7814\u7a76\u65b9\u5411\u3002<\/p>\n\n\n\n<p><strong>\u9060\u5fd7\u555f\u52d5<\/strong><strong> BDNF-TrkB <\/strong><strong>\u4fc3\u9032\u6d77\u99ac\u795e\u7d93\u767c\u751f<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u9060\u5fd7\u555f\u52d5 BDNF-TrkB \u4fc3\u9032\u6d77\u99ac\u795e\u7d93\u767c\u751f\uff08Sci Adv. 2025\uff09\u300d\u3002<\/p>\n\n\n\n<p>\u9060\u5fd7\uff08Polygala tenuifolia\uff09\u4f5c\u70ba\u4e00\u7a2e\u5e38\u7528\u4e2d\u85e5\uff0c\u5df2\u88ab\u8b49\u5be6\u5177\u6709\u6297\u6291\u9b31\u6a23\u4f5c\u7528\u3002\u591a\u9805\u7814\u7a76\u8868\u660e\uff0c\u9060\u5fd7\u63d0\u53d6\u7269\u80fd\u5920\u589e\u52a0\u8166\u6e90\u6027\u795e\u7d93\u71df\u990a\u56e0\u5b50 (BDNF) \u7684\u8868\u9054\uff0c\u4e26\u6d3b\u5316\u5176\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176B (TrkB) \u4fe1\u865f\u901a\u8def\uff0c\u9032\u800c\u4fc3\u9032\u6d77\u99ac\u795e\u7d93\u767c\u751f <sup>34<\/sup>\u3002BDNF\u5728\u795e\u7d93\u5143\u7684\u751f\u5b58\u3001\u5206\u5316\u3001\u7a81\u89f8\u53ef\u5851\u6027\u3001\u795e\u7d93\u767c\u751f\u3001\u5b78\u7fd2\u548c\u8a18\u61b6\u4ee5\u53ca\u60c5\u7dd2\u8abf\u7bc0\u4e2d\u626e\u6f14\u95dc\u9375\u89d2\u8272 <sup>38<\/sup>\u3002\u6d77\u99ac\u795e\u7d93\u767c\u751f\u53d7\u640d\u8207\u6291\u9b31\u75c7\u7684\u8a8d\u77e5\u8870\u9000\u5bc6\u5207\u76f8\u95dc <sup>34<\/sup>\u3002\u9060\u5fd7\u900f\u904eBDNF-TrkB\u901a\u8def\u7684\u6d3b\u5316\uff0c\u6709\u52a9\u65bc\u4fee\u5fa9\u53d7\u640d\u7684\u795e\u7d93\u7db2\u7d61\uff0c\u6539\u5584\u5b78\u7fd2\u8a18\u61b6\u80fd\u529b <sup>34<\/sup>\u3002<\/p>\n\n\n\n<p>\u5118\u7ba1\u539f\u59cb\u6a21\u578b\u4e2d\u5f15\u7528\u7684\u300cSci Adv. 2025\u300d\u70ba\u672a\u4f86\u5e74\u4efd\u7684\u6587\u737b\uff0c\u4f46\u9060\u5fd7\u6d3b\u5316BDNF-TrkB\u4e26\u4fc3\u9032\u6d77\u99ac\u795e\u7d93\u767c\u751f\u7684\u6a5f\u5236\uff0c\u5728\u73fe\u6709\u7814\u7a76\u4e2d\u5df2\u7372\u5f97\u5145\u5206\u652f\u6301 <sup>34<\/sup>\u3002\u9019\u8868\u660e\u9060\u5fd7\u5728\u6539\u5584\u6291\u9b31\u75c7\u76f8\u95dc\u7684\u795e\u7d93\u53ef\u5851\u6027\u7f3a\u9677\u65b9\u9762\u5177\u6709\u986f\u8457\u6f5b\u529b\u3002<\/p>\n\n\n\n<p><strong>\u6894\u5b50\u963b\u65b7<\/strong><strong> CRF <\/strong><strong>\u53d7\u9ad4\u6291\u5236<\/strong><strong> HPA <\/strong><strong>\u8ef8\u904e\u5ea6\u555f\u52d5<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u6894\u5b50\u963b\u65b7 CRF \u53d7\u9ad4\u6291\u5236 HPA \u8ef8\u904e\u5ea6\u555f\u52d5\uff08PNAS. 2024\uff09\u300d\u3002<\/p>\n\n\n\n<p>\u6894\u5b50\uff08Gardenia jasminoides\uff09\u662f\u4e00\u7a2e\u5177\u6709\u5ee3\u6cdb\u751f\u7269\u6d3b\u6027\u7684\u4e2d\u85e5\uff0c\u5305\u62ec\u6297\u708e\u548c\u795e\u7d93\u4fdd\u8b77\u4f5c\u7528 <sup>39<\/sup>\u3002\u4fc3\u814e\u4e0a\u817a\u76ae\u8cea\u6fc0\u7d20\u91cb\u653e\u56e0\u5b50\u53d7\u9ad42 (CRFR2) \u662f\u4fc3\u814e\u4e0a\u817a\u76ae\u8cea\u6fc0\u7d20\u91cb\u653e\u56e0\u5b50 (CRF) \u7684\u53d7\u9ad4\uff0c\u800cCRF\u662fHPA\u8ef8\u7684\u95dc\u9375\u8abf\u7bc0\u56e0\u5b50 <sup>41<\/sup>\u3002HPA\u8ef8\u7684\u904e\u5ea6\u6d3b\u5316\u662f\u7126\u616e\u548c\u6291\u9b31\u75c7\u7684\u5171\u540c\u75c5\u7406\u751f\u7406\u5b78\u7279\u5fb5 <sup>3<\/sup>\u3002\u6709\u7814\u7a76\u63d0\u53ca\u6894\u5b50\u679c\u5be6\u63d0\u53d6\u7269\u8207CRF-R2\u76f8\u95dc <sup>42<\/sup>\uff0c\u4e14\u6894\u5b50\u53ef\u5c0e\u81f4CRF-R2\u7684\u8870\u6e1b <sup>41<\/sup>\u3002<\/p>\n\n\n\n<p>\u5118\u7ba1\u539f\u59cb\u6a21\u578b\u4e2d\u5f15\u7528\u7684\u300cPNAS. 2024\u300d\u70ba\u672a\u4f86\u5e74\u4efd\u7684\u6587\u737b\uff0c\u4f46\u6894\u5b50\u900f\u904e\u8abf\u7bc0HPA\u8ef8\u4f86\u6291\u5236\u5176\u904e\u5ea6\u6d3b\u5316\u7684\u6982\u5ff5\u662f\u5408\u7406\u7684\uff0c\u5c24\u5176\u8003\u616e\u5230\u5176\u6297\u708e\u548c\u61c9\u6fc0\u8abf\u7bc0\u7684\u6f5b\u529b\u3002\u7136\u800c\uff0c\u95dc\u65bc\u6894\u5b50\u662f\u5426\u76f4\u63a5\u300c\u963b\u65b7CRF\u53d7\u9ad4\u300d\u7684\u5177\u9ad4\u5206\u5b50\u6a5f\u5236\uff0c\u6240\u63d0\u4f9b\u7684\u8cc7\u6599\u50c5\u63d0\u53ca\u300cCRF-R2 attenuation\u300d\uff0c\u9019\u53ef\u80fd\u610f\u5473\u8457\u591a\u7a2e\u8abf\u7bc0\u65b9\u5f0f\uff0c\u800c\u4e0d\u50c5\u50c5\u662f\u76f4\u63a5\u963b\u65b7\u3002\u56e0\u6b64\uff0c\u61c9\u4fee\u6b63\u70ba\uff1a\u6894\u5b50\u53ef\u80fd\u900f\u904e\u8abf\u7bc0CRF\u53d7\u9ad4\u76f8\u95dc\u901a\u8def\u4f86\u6291\u5236HPA\u8ef8\u7684\u904e\u5ea6\u6d3b\u5316\uff0c\u9019\u8207\u5176\u6297\u708e\u548c\u60c5\u7dd2\u8abf\u7bc0\u4f5c\u7528\u76f8\u7b26\uff0c\u4f46\u5176\u7cbe\u78ba\u7684\u5206\u5b50\u4f5c\u7528\u6a5f\u5236\u4ecd\u9700\u66f4\u8a73\u7d30\u7684\u95e1\u660e\u3002<\/p>\n\n\n\n<p><strong>\u6cbb\u7642\u8def\u5f91\u7684\u5206\u5b50\u6574\u5408<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u672c\u6a21\u578b\u63d0\u51fa\u4e2d\u85e5\u6cbb\u7642\u7684\u591a\u5c64\u6b21\u5e72\u9810\u7b56\u7565\uff0c\u65e8\u5728\u5f9e\u80fd\u91cf\u3001\u795e\u7d93\u3001\u708e\u75c7\u548c\u53ef\u5851\u6027\u7b49\u591a\u500b\u5c64\u9762\u6062\u5fa9\u751f\u7406\u5e73\u8861\u3002<\/p>\n\n\n\n<p><strong>\u80fd\u91cf\u5c64<\/strong><strong> [<\/strong><strong>\u80fd\u91cf\u4fee\u5fa9<\/strong><strong>] &#8211;&gt; <\/strong><strong>\u725b\u819d<\/strong><strong>\/<\/strong><strong>\u9ec3\u67cf<\/strong><strong>: <\/strong><strong>\u555f\u52d5<\/strong><strong>AMPK\/PGC-1\u03b1 &#8211;&gt; <\/strong><strong>\u7dda\u7c92\u9ad4\u65b0\u751f<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u80fd\u91cf\u5c64 [\u80fd\u91cf\u4fee\u5fa9] &#8211;&gt; \u725b\u819d\/\u9ec3\u67cf: \u555f\u52d5AMPK\/PGC-1\u03b1 &#8211;&gt; \u7dda\u7c92\u9ad4\u65b0\u751f\u300d\u3002<\/p>\n\n\n\n<p>PGC-1\u03b1\uff08\u904e\u6c27\u5316\u7269\u9176\u9ad4\u589e\u6b96\u7269\u6d3b\u5316\u53d7\u9ad4\u03b3\u8f14\u6d3b\u5316\u56e0\u5b501\u03b1\uff09\u88ab\u5ee3\u6cdb\u8a8d\u70ba\u662f\u7dda\u7c92\u9ad4\u751f\u7269\u5408\u6210\u548c\u80fd\u91cf\u4ee3\u8b1d\u7684\u4e3b\u8981\u8abf\u7bc0\u56e0\u5b50\uff0c\u5176\u6d3b\u6027\u53d7AMPK\uff08AMP\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff09\u7684\u8abf\u7bc0 <sup>24<\/sup>\u3002AMPK\u548cSIRT1\uff08\u53bb\u4e59\u9170\u5316\u9176\uff09\u88ab\u63cf\u8ff0\u70ba\u76f4\u63a5\u5f71\u97ffPGC-1\u03b1\u6d3b\u6027\u7684\u4ee3\u8b1d\u50b3\u611f\u5668\uff0c\u5171\u540c\u69cb\u6210\u4e00\u500b\u8abf\u7bc0\u7d30\u80de\u80fd\u91cf\u6d88\u8017\u7684\u7db2\u7d61 <sup>43<\/sup>\u3002\u725b\u819d\uff08Achyranthes bidentata\uff09\u7684\u63d0\u53d6\u7269\u5df2\u88ab\u8b49\u660e\u80fd\u5920\u900f\u904e\u8abf\u7bc0AMPK-SIRT3\u4fe1\u865f\u901a\u8def\uff0c\u6539\u5584\u7dda\u7c92\u9ad4\u547c\u5438\u529f\u80fd\u969c\u7919\u4e26\u589e\u52a0ATP\u7522\u751f <sup>47<\/sup>\u3002\u9019\u652f\u6301\u4e86\u725b\u819d\u5728\u80fd\u91cf\u4fee\u5fa9\u5c64\u9762\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u95dc\u65bc\u9ec3\u67cf\uff08Phellodendron amurense\uff09\u5728\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599\u4e2d\uff0c\u4e26\u672a\u76f4\u63a5\u63d0\u53ca\u5176\u8207AMPK\/PGC-1\u03b1\u6d3b\u5316\u6216\u7dda\u7c92\u9ad4\u65b0\u751f\u4e4b\u9593\u7684\u5177\u9ad4\u95dc\u806f\u3002\u5118\u7ba1PGC-1\u03b1\u5728\u809d\u81df\u548c\u80f0\u817a\u03b2\u7d30\u80de\u4e2d\u8868\u9054\uff0c\u4e26\u8207\u7cd6\u5c3f\u75c5\u548c\u80f0\u817a\u708e\u7b49\u75be\u75c5\u76f8\u95dc <sup>44<\/sup>\uff0c\u4f46\u9019\u4e9b\u8cc7\u6599\u4e26\u672a\u5c07\u9ec3\u67cf\u8207\u9019\u4e9b\u6a5f\u5236\u76f4\u63a5\u806f\u7e6b\u8d77\u4f86\u3002\u56e0\u6b64\uff0c\u61c9\u4fee\u6b63\u70ba\uff1a\u725b\u819d\u900f\u904e\u6d3b\u5316AMPK\/PGC-1\u03b1\u901a\u8def\uff0c\u4fc3\u9032\u7dda\u7c92\u9ad4\u65b0\u751f\u4e26\u6539\u5584\u80fd\u91cf\u4ee3\u8b1d\uff0c\u5f9e\u800c\u89e3\u6c7a\u80fd\u91cf\u5371\u6a5f\uff0c\u9019\u5728\u80fd\u91cf\u4fee\u5fa9\u5c64\u9762\u5177\u6709\u6f5b\u529b\u3002\u7136\u800c\uff0c\u9ec3\u67cf\u5728\u6b64\u6a5f\u5236\u4e2d\u7684\u5177\u9ad4\u4f5c\u7528\uff0c\u5728\u73fe\u6709\u8cc7\u6599\u4e2d\u7f3a\u4e4f\u76f4\u63a5\u8b49\u64da\u3002<\/p>\n\n\n\n<p><strong>\u795e\u7d93\u5c64<\/strong><strong> &#8211;&gt; <\/strong><strong>\u828d\u85e5<\/strong><strong>\/<\/strong><strong>\u9178\u68d7\u4ec1<\/strong><strong>: <\/strong><strong>\u9776\u5411<\/strong><strong>\u03b15<\/strong><strong>\u4e9e\u57fa<\/strong><strong> &#8211;&gt; <\/strong><strong>\u6062\u5fa9\u6291\u5236\u5e73\u8861<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u795e\u7d93\u5c64 &#8211;&gt; \u828d\u85e5\/\u9178\u68d7\u4ec1: \u9776\u5411\u03b15\u4e9e\u57fa &#8211;&gt; \u6062\u5fa9\u6291\u5236\u5e73\u8861\u300d\u3002<\/p>\n\n\n\n<p>\u9178\u68d7\u4ec1\uff08Ziziphus jujuba\uff09\u63d0\u53d6\u7269\u5df2\u88ab\u8b49\u660e\u5728\u9ad4\u5916\u5be6\u9a57\u4e2d\u80fd\u4e0a\u8abfGABAA\u53d7\u9ad4\u03b11\u548c\u03b13\u4e9e\u57fa\u7684mRNA\u6c34\u5e73\uff0c\u4e26\u8abf\u7bc0GABA\u80fd\u7a81\u89f8\u901a\u8def\uff0c\u9019\u8207\u5176\u6297\u7126\u616e\u4f5c\u7528\u76f8\u95dc <sup>26<\/sup>\u3002GABAA\u53d7\u9ad4\u03b15\u4e9e\u57fa\u5728\u6d77\u99ac\u9ad4\u4e2d\u9ad8\u5ea6\u8868\u9054\uff0c\u4ecb\u5c0e\u5f35\u529b\u6027\u6291\u5236\uff0c\u5c0d\u7126\u616e\u548c\u8a18\u61b6\u6709\u5f71\u97ff <sup>13<\/sup>\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u5728\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599\u4e2d\uff0c<strong>\u6c92\u6709\u76f4\u63a5\u8b49\u64da\u8868\u660e\u828d\u85e5\uff08<\/strong><strong>Paeonia lactiflora<\/strong><strong>\uff09\u80fd\u5920\u9776\u5411<\/strong><strong>GABAA \u03b15<\/strong><strong>\u4e9e\u57fa\u6216\u53c3\u8207<\/strong><strong>GABA<\/strong><strong>\u80fd\u7cfb\u7d71\u7684\u91cd\u5efa<\/strong>\u3002\u96d6\u7136\u6709\u7814\u7a76\u8a0e\u8ad6\u4e86GABAA \u03b15\u4e9e\u57fa\u5728\u6d77\u99ac\u9ad4\u4e2d\u7684\u4f5c\u7528 <sup>18<\/sup>\uff0c\u4f46\u828d\u85e5\u4e26\u672a\u88ab\u63d0\u53ca\u3002\u56e0\u6b64\uff0c\u61c9\u4fee\u6b63\u70ba\uff1a\u9178\u68d7\u4ec1\u900f\u904e\u8abf\u7bc0GABA\u80fd\u7cfb\u7d71\uff0c\u53ef\u80fd\u4fc3\u9032GABA\u80fd\u6291\u5236\u5e73\u8861\u7684\u6062\u5fa9\u3002\u7136\u800c\uff0c\u828d\u85e5\u662f\u5426\u900f\u904e\u9776\u5411GABAA \u03b15\u4e9e\u57fa\u4f86\u767c\u63ee\u4f5c\u7528\uff0c\u5728\u73fe\u6709\u8cc7\u6599\u4e2d\u7f3a\u4e4f\u76f4\u63a5\u8b49\u64da\u3002<\/p>\n\n\n\n<p><strong>\u708e\u75c7\u5c64<\/strong><strong> [<\/strong><strong>\u6297\u708e\u901a\u8def<\/strong><strong>] &#8211;&gt; <\/strong><strong>\u67f4\u80e1<\/strong><strong>\/<\/strong><strong>\u6894\u5b50<\/strong><strong>: <\/strong><strong>\u6291\u5236<\/strong><strong>NF-\u03baB\/CRF &#8211;&gt; <\/strong><strong>\u964d\u4f4e<\/strong><strong>TNF-\u03b1 50%<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u708e\u75c7\u5c64 [\u6297\u708e\u901a\u8def] &#8211;&gt; \u67f4\u80e1\/\u6894\u5b50: \u6291\u5236NF-\u03baB\/CRF &#8211;&gt; \u964d\u4f4eTNF-\u03b1 50%\u300d\u3002<\/p>\n\n\n\n<p>\u67f4\u80e1\uff08Bupleurum chinense\uff09\u5177\u6709\u6297\u708e\u4f5c\u7528\uff0c\u4e26\u5df2\u88ab\u8b49\u5be6\u80fd\u986f\u8457\u964d\u4f4e\u4fc3\u708e\u7d30\u80de\u56e0\u5b50TNF-\u03b1\u7684\u6c34\u5e73 <sup>32<\/sup>\u3002\u6894\u5b50\uff08Gardenia jasminoides\uff09\u4e5f\u5c55\u73fe\u51fa\u5ee3\u8b5c\u7684\u6297\u708e\u6d3b\u6027\uff0c\u5176\u6d3b\u6027\u6210\u5206\u5982\u6894\u5b50\u82f7\u53ef\u6291\u5236T\u7d30\u80de\u6d3b\u5316\u548c\u708e\u75c7\u53cd\u61c9 <sup>39<\/sup>\u3002\u6162\u6027\u58d3\u529b\u53ef\u6d3b\u5316NF-\u03baB\u901a\u8def\uff0c\u5c0e\u81f4TNF-\u03b1\u548cIL-6\u7b49\u4fc3\u708e\u7d30\u80de\u56e0\u5b50\u7684\u5347\u9ad8 <sup>3<\/sup>\u3002\u6894\u5b50\u8207CRF\u53d7\u9ad4\u76f8\u95dc\uff0c\u53ef\u80fd\u900f\u904e\u8abf\u7bc0HPA\u8ef8\u4f86\u6291\u5236\u61c9\u6fc0\u53cd\u61c9 <sup>41<\/sup>\u3002<\/p>\n\n\n\n<p>\u5118\u7ba1\u67f4\u80e1\u548c\u6894\u5b50\u90fd\u5177\u6709\u6297\u708e\u4f5c\u7528\uff0c\u4e14\u67f4\u80e1\u53ef\u964d\u4f4eTNF-\u03b1\uff0c\u4f46\u6240\u63d0\u4f9b\u7684\u8cc7\u6599\u4e2d<strong>\u6c92\u6709\u76f4\u63a5\u8b49\u64da\u652f\u6301\u300c\u964d\u4f4e<\/strong><strong>TNF-\u03b1 50%<\/strong><strong>\u300d\u9019\u4e00\u5177\u9ad4\u91cf\u5316\u6578\u64da<\/strong>\u3002\u6b64\u5916\uff0c\u96d6\u7136NF-\u03baB\u548cCRF\u901a\u8def\u8207\u708e\u75c7\u548c\u61c9\u6fc0\u53cd\u61c9\u5bc6\u5207\u76f8\u95dc\uff0c\u4f46\u4e2d\u85e5\u5c0d\u9019\u4e9b\u901a\u8def\u7684\u5177\u9ad4\u6291\u5236\u767e\u5206\u6bd4\u4e5f\u672a\u88ab\u91cf\u5316\u3002\u56e0\u6b64\uff0c\u61c9\u4fee\u6b63\u70ba\uff1a\u67f4\u80e1\u548c\u6894\u5b50\u900f\u904e\u6297\u708e\u901a\u8def\uff0c\u53ef\u80fd\u6291\u5236NF-\u03baB\u548cCRF\u76f8\u95dc\u4fe1\u865f\uff0c\u5f9e\u800c\u964d\u4f4e\u4fc3\u708e\u7d30\u80de\u56e0\u5b50\uff08\u5982TNF-\u03b1\u548cIL-6\uff09\u7684\u6c34\u5e73\uff0c\u6709\u52a9\u65bc\u7de9\u89e3\u795e\u7d93\u708e\u75c7\u3002\u7136\u800c\uff0c\u95dc\u65bc\u964d\u4f4eTNF-\u03b1\u905450%\u7684\u5177\u9ad4\u91cf\u5316\u6548\u679c\uff0c\u4ecd\u9700\u9032\u4e00\u6b65\u7684\u5be6\u9a57\u9a57\u8b49\u3002<\/p>\n\n\n\n<p><strong>\u53ef\u5851\u5c64<\/strong><strong> [<\/strong><strong>\u7a81\u89f8\u4fee\u5fa9<\/strong><strong>] &#8211;&gt; <\/strong><strong>\u9060\u5fd7<\/strong><strong>: BDNF\u2191 &#8211;&gt; <\/strong><strong>\u6a39\u7a81\u68d8\u5bc6\u5ea6\u589e\u52a0<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u53ef\u5851\u5c64 [\u7a81\u89f8\u4fee\u5fa9] &#8211;&gt; \u9060\u5fd7: BDNF\u2191 &#8211;&gt; \u6a39\u7a81\u68d8\u5bc6\u5ea6\u589e\u52a0\u300d\u3002<\/p>\n\n\n\n<p>\u9060\u5fd7\uff08Polygala tenuifolia\uff09\u5df2\u88ab\u8b49\u660e\u80fd\u5920\u6d3b\u5316BDNF-TrkB\u4fe1\u865f\u901a\u8def\uff0c\u4fc3\u9032\u6d77\u99ac\u795e\u7d93\u767c\u751f <sup>34<\/sup>\u3002BDNF\u5728\u795e\u7d93\u5143\u767c\u80b2\u3001\u7a81\u89f8\u53ef\u5851\u6027\u3001\u795e\u7d93\u767c\u751f\u3001\u5b78\u7fd2\u548c\u8a18\u61b6\u4e2d\u626e\u6f14\u95dc\u9375\u89d2\u8272 <sup>38<\/sup>\u3002PGC-1\u03b1\u7684\u904e\u5ea6\u8868\u9054\u5df2\u88ab\u8b49\u5be6\u80fd\u589e\u52a0\u6a39\u7a81\u68d8\u5bc6\u5ea6\u4e26\u589e\u5f37\u7a81\u89f8\u5206\u5316\uff0c\u9019\u8868\u660e\u7dda\u7c92\u9ad4\u529f\u80fd\u8207\u7a81\u89f8\u53ef\u5851\u6027\u4e4b\u9593\u5b58\u5728\u5bc6\u5207\u806f\u7e6b <sup>49<\/sup>\u3002\u7531\u65bc\u9060\u5fd7\u900f\u904eBDNF\u4fc3\u9032\u795e\u7d93\u53ef\u5851\u6027\uff0c\u9019\u8207\u589e\u52a0\u6a39\u7a81\u68d8\u5bc6\u5ea6\u4ee5\u4fee\u5fa9\u7a81\u89f8\u529f\u80fd\u7684\u6982\u5ff5\u662f\u9ad8\u5ea6\u4e00\u81f4\u7684\u3002<\/p>\n\n\n\n<p>\u6b64\u8655\u7684\u6a5f\u5236\u63cf\u8ff0\u8207\u73fe\u6709\u8b49\u64da\u9ad8\u5ea6\u543b\u5408\uff0c\u652f\u6301\u9060\u5fd7\u5728\u795e\u7d93\u53ef\u5851\u6027\u4fee\u5fa9\u4e2d\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n<p><strong>\u7b2c\u4e09\u7ae0\uff1a\u5c0d\u6bd4\u897f\u85e5\u6cbb\u7642\u7684\u5206\u5b50\u512a\u52e2<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u672c\u7ae0\u5c07\u5c0d\u4e2d\u85e5\u6574\u5408\u65b9\u6848\u8207\u50b3\u7d71\u897f\u85e5\uff08\u5982SSRI\uff09\u5728\u5206\u5b50\u5c64\u9762\u7684\u6cbb\u7642\u9776\u9ede\u3001\u6548\u679c\u53ca\u505c\u85e5\u53cd\u61c9\u9032\u884c\u5c0d\u6bd4\u5206\u6790\u3002<\/p>\n\n\n\n<p><strong>\u6cbb\u7642\u9776\u9ede<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>SSRI<\/strong><strong>\uff08\u6c1f\u897f\u6c40\uff09<\/strong><strong> vs. <\/strong><strong>\u4e2d\u85e5\u6574\u5408\u65b9\u6848<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>5-HT <\/strong><strong>\u8f49\u904b\u9ad4\u5f37\u5236\u963b\u65b7<\/strong><strong> \u2192 <\/strong><strong>\u521d\u671f\u7126\u616e\u52a0\u91cd<\/strong><strong> vs. <\/strong><strong>\u6894\u5b50\u8abf\u7bc0<\/strong><strong> 5-HT1A <\/strong><strong>\u81ea\u53d7\u9ad4\u907f\u514d\u7a81\u89f8\u9593\u9699<\/strong><strong> 5-HT <\/strong><strong>\u66b4\u6f32<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u9078\u64c7\u6027\u8840\u6e05\u7d20\u518d\u651d\u53d6\u6291\u5236\u5291 (SSRIs) \u5982\u820d\u66f2\u6797\uff0c\u900f\u904e\u7d50\u5408\u8840\u6e05\u7d20\u8f49\u904b\u9ad4 (SERT) \u6291\u5236\u795e\u7d93\u5143\u5c0d\u8840\u6e05\u7d20\u7684\u518d\u651d\u53d6\uff0c\u5f9e\u800c\u589e\u5f37\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u7684\u8840\u6e05\u7d20\u80fd\u6d3b\u6027 <sup>50<\/sup>\u3002\u9019\u7a2e\u6a5f\u5236\u6703\u5c0e\u81f4\u7a81\u89f8\u524d5-HT1A\u81ea\u53d7\u9ad4\u7684\u4e0b\u8abf\uff0c\u800c5-HT1A\u81ea\u53d7\u9ad4\u901a\u5e38\u900f\u904e\u8ca0\u53cd\u994b\u6291\u5236\u8840\u6e05\u7d20\u7684\u91cb\u653e <sup>50<\/sup>\u3002SSRIs\u7684\u6cbb\u7642\u6548\u679c\u5ef6\u9072\uff0c\u90e8\u5206\u539f\u56e0\u88ab\u8a8d\u70ba\u662f\u9019\u4e9b\u81ea\u53d7\u9ad4\u7684\u812b\u654f\u904e\u7a0b <sup>51<\/sup>\u3002\u5728\u6cbb\u7642\u521d\u671f\uff0c\u7a81\u89f8\u9593\u9699\u8840\u6e05\u7d20\u7684\u6025\u6027\u5347\u9ad8\u53ef\u80fd\u5c0e\u81f4\u90e8\u5206\u60a3\u8005\u7126\u616e\u52a0\u91cd\uff0c\u9019\u662f\u4e00\u500b\u5df2\u77e5\u7684\u526f\u4f5c\u7528\u3002<\/p>\n\n\n\n<p>\u6894\u5b50\uff08Gardenia jasminoides\uff09\u542b\u6709\u6d3b\u6027\u6210\u5206\u5982\u6894\u5b50\u82f7\uff0c\u6709\u7814\u7a76\u63d0\u53ca\u5176\u82075-HT1A\u81ea\u53d7\u9ad4\u7684\u8abf\u7bc0\u76f8\u95dc <sup>54<\/sup>\u30025-HT1A\u81ea\u53d7\u9ad4\u5c31\u50cf\u8840\u6e05\u7d20\u795e\u7d93\u5143\u7684\u300c\u9ad8\u901f\u516c\u8def\u5de1\u8b66\u300d\uff0c\u5728\u8840\u6e05\u7d20\u91cb\u653e\u904e\u5feb\u6642\u767c\u51fa\u300c\u6e1b\u901f\u300d\u4fe1\u865f <sup>53<\/sup>\u3002\u56e0\u6b64\uff0c\u6894\u5b50\u82e5\u80fd\u8abf\u7bc05-HT1A\u81ea\u53d7\u9ad4\uff0c\u53ef\u80fd\u907f\u514dSSRIs\u521d\u671f\u56e0\u8840\u6e05\u7d20\u9a5f\u7136\u5347\u9ad8\u800c\u5f15\u8d77\u7684\u300c\u66b4\u6f32\u300d\u73fe\u8c61\uff0c\u5f9e\u800c\u6e1b\u5c11\u521d\u671f\u7126\u616e\u7684\u52a0\u91cd\u3002\u7136\u800c\uff0c\u6240\u63d0\u4f9b\u7684\u8cc7\u6599\u4e26\u672a\u76f4\u63a5\u63d0\u4f9b\u6894\u5b50\u7cbe\u78ba\u8abf\u7bc05-HT1A\u81ea\u53d7\u9ad4\u4ee5\u300c\u907f\u514d\u7a81\u89f8\u9593\u96995-HT\u66b4\u6f32\u300d\u7684\u76f4\u63a5\u91cf\u5316\u6216\u6a5f\u5236\u6bd4\u8f03\u3002\u5176\u4f5c\u7528\u53ef\u80fd\u66f4\u5074\u91cd\u65bc\u6574\u9ad4\u8840\u6e05\u7d20\u80fd\u7cfb\u7d71\u7684\u5e73\u8861\u8abf\u7bc0\u3002<\/p>\n\n\n\n<p><strong>BDNF <\/strong><strong>\u901a\u8def\u7528\u85e5<\/strong><strong> 4 <\/strong><strong>\u5468\u5f8c\u624d\u7de9\u6162\u63d0\u5347<\/strong><strong> BDNF vs. <\/strong><strong>\u9060\u5fd7<\/strong><strong> 72 <\/strong><strong>\u5c0f\u6642\u5167\u555f\u52d5<\/strong><strong> TrkB <\/strong><strong>\u5feb\u901f\u6297\u6291\u9b31\uff08\u52d5\u7269\u6a21\u578b\u5feb<\/strong><strong> 3 <\/strong><strong>\u500d\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p>SSRIs \u6cbb\u7642\u5f8c\uff0cBDNF\uff08\u8166\u6e90\u6027\u795e\u7d93\u71df\u990a\u56e0\u5b50\uff09\u6c34\u5e73\u7684\u63d0\u5347\u901a\u5e38\u662f\u5ef6\u9072\u7684 <sup>50<\/sup>\u3002\u81e8\u5e8a\u7814\u7a76\u986f\u793a\uff0cBDNF\u6c34\u5e73\u7684\u986f\u8457\u63d0\u5347\u53ef\u80fd\u9700\u8981\u6578\u6708\u6642\u9593\uff0c\u4f8b\u5982\u51a5\u60f3\u8a13\u7df4\u5728\u5065\u5eb7\u6210\u4eba\u4e2d\u53ef\u5c0e\u81f4BDNF\u57283\u30016\u30019\u500b\u6708\u5f8c\u7d2f\u7a4d\u6027\u589e\u52a0 <sup>57<\/sup>\u3002<\/p>\n\n\n\n<p>\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u9060\u5fd7\uff08Polygala tenuifolia\uff09\u63d0\u53d6\u7269\u5728\u52d5\u7269\u6a21\u578b\u4e2d\u5c55\u73fe\u51fa\u5feb\u901f\u7684\u6297\u6291\u9b31\u6a23\u6548\u679c\uff0c\u80fd\u5728\u6578\u5206\u9418\u6216\u6578\u5c0f\u6642\u5167\u6d3b\u5316BDNF-TrkB\u4fe1\u865f\u901a\u8def\u4e26\u8a98\u767cBDNF\u8868\u9054 <sup>36<\/sup>\u3002\u96d6\u7136\u539f\u59cb\u6a21\u578b\u8072\u7a31\u300c\u5feb3\u500d\u300d\u7684\u5177\u9ad4\u901f\u5ea6\u63d0\u5347\u672a\u5728\u6240\u63d0\u4f9b\u7684\u8cc7\u6599\u4e2d\u660e\u78ba\u91cf\u5316\uff0c\u4f46\u300c\u5feb\u901f\u6297\u6291\u9b31\u300d\u7684\u7279\u6027\u662f\u7372\u5f97\u652f\u6301\u7684\u3002\u9019\u8868\u660e\u9060\u5fd7\u53ef\u80fd\u900f\u904e\u66f4\u76f4\u63a5\u6216\u5feb\u901f\u7684\u6a5f\u5236\u555f\u52d5BDNF\u901a\u8def\uff0c\u5f9e\u800c\u5728\u8d77\u6548\u6642\u9593\u4e0a\u512a\u65bc\u50b3\u7d71SSRIs\u3002<\/p>\n\n\n\n<p><strong>\u7dda\u7c92\u9ad4\u529f\u80fd\u6291\u5236\u8907\u5408\u9ad4<\/strong><strong> IV \u2192 ATP <\/strong><strong>\u9032\u4e00\u6b65\u4e0b\u964d<\/strong><strong> vs. <\/strong><strong>\u725b\u819d\u63d0\u5347<\/strong><strong> ATP <\/strong><strong>\u5408\u6210\u6548\u7387<\/strong><strong> 35% <\/strong><strong>\u6539\u5584\u80fd\u91cf\u5371\u6a5f\u6838\u5fc3\u75c5\u7406<\/strong><strong><\/strong><\/p>\n\n\n\n<p>SSRIs\uff08\u5982\u820d\u66f2\u6797\u3001\u6c1f\u897f\u6c40\u3001\u4f9d\u897f\u915e\u666e\u862d\u3001\u5e15\u7f85\u897f\u6c40\uff09\u5728\u9ad8\u6fc3\u5ea6\u4e0b\u53ef\u80fd\u6291\u5236\u7dda\u7c92\u9ad4\u8907\u5408\u9ad4I\u548cIV\u7684\u6d3b\u6027\uff0c\u9019\u53ef\u80fd\u5c0e\u81f4ATP\u751f\u7522\u53d7\u640d <sup>4<\/sup>\u3002\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u6703\u5c0e\u81f4ATP\u751f\u6210\u6e1b\u5c11\uff0c\u9032\u800c\u5f71\u97ff\u7d30\u80de\u80fd\u91cf\u5e73\u8861 <sup>4<\/sup>\u3002<\/p>\n\n\n\n<p>\u725b\u819d\uff08Achyranthes bidentata\uff09\u7684\u6d3b\u6027\u6210\u5206\u5df2\u88ab\u8b49\u660e\u80fd\u900f\u904e\u8abf\u7bc0AMPK-SIRT3\u4fe1\u865f\u901a\u8def\uff0c\u6539\u5584\u7dda\u7c92\u9ad4\u547c\u5438\u529f\u80fd\u969c\u7919\u4e26\u589e\u52a0ATP\u7522\u751f <sup>47<\/sup>\u3002\u9019\u8868\u660e\u725b\u819d\u80fd\u5920\u76f4\u63a5\u91dd\u5c0d\u6291\u9b31\u75c7\u7684\u80fd\u91cf\u4ee3\u8b1d\u5371\u6a5f\u3002\u7136\u800c\uff0c\u539f\u59cb\u6a21\u578b\u4e2d\u300c\u63d0\u5347ATP\u5408\u6210\u6548\u738735%\u300d\u7684\u5177\u9ad4\u91cf\u5316\u6578\u64da\uff0c\u5728\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599\u4e2d\u4e26\u672a\u76f4\u63a5\u627e\u5230\u652f\u6301 <sup>58<\/sup>\u3002\u5118\u7ba1\u725b\u819d\u78ba\u5be6\u80fd\u6539\u5584\u7dda\u7c92\u9ad4\u529f\u80fd\u548cATP\u7522\u751f\uff0c\u4f46\u8a72\u5177\u9ad4\u767e\u5206\u6bd4\u4ecd\u9700\u66f4\u56b4\u8b39\u7684\u5be6\u8b49\u3002<\/p>\n\n\n\n<p><strong>\u505c\u85e5\u53cd\u61c9<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>50% <\/strong><strong>\u60a3\u8005\u5fa9\u767c\uff08<\/strong><strong>BDNF <\/strong><strong>\u56de\u843d\uff09<\/strong><strong> vs. PGC-1\u03b1 <\/strong><strong>\u6301\u7e8c\u8868\u9054<\/strong><strong> &gt;8 <\/strong><strong>\u5468\u9577\u6548\u795e\u7d93\u53ef\u5851\u6027\u91cd\u5efa<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u50b3\u7d71\u6297\u6291\u9b31\u85e5\u7269\u505c\u85e5\u5f8c\uff0c\u60a3\u8005\u5fa9\u767c\u7387\u8f03\u9ad8\uff0cBDNF\u6c34\u5e73\u7684\u56de\u843d\u88ab\u8a8d\u70ba\u662f\u6f5b\u5728\u539f\u56e0\u4e4b\u4e00 <sup>38<\/sup>\u3002\u5118\u7ba1\u539f\u59cb\u6a21\u578b\u4e2d\u300c50%\u60a3\u8005\u5fa9\u767c\u300d\u7684\u5177\u9ad4\u767e\u5206\u6bd4\u672a\u5728\u55ae\u4e00\u8cc7\u6599\u4e2d\u76f4\u63a5\u91cf\u5316\uff0c\u4f46\u9ad8\u5fa9\u767c\u7387\u662fSSRIs\u6cbb\u7642\u7684\u666e\u904d\u6311\u6230\u3002<\/p>\n\n\n\n<p>PGC-1\u03b1\uff08\u904e\u6c27\u5316\u7269\u9176\u9ad4\u589e\u6b96\u7269\u6d3b\u5316\u53d7\u9ad4\u03b3\u8f14\u6d3b\u5316\u56e0\u5b501\u03b1\uff09\u4f5c\u70ba\u7dda\u7c92\u9ad4\u751f\u7269\u5408\u6210\u548c\u529f\u80fd\u7684\u4e3b\u8981\u8abf\u7bc0\u56e0\u5b50\uff0c\u5176\u904e\u5ea6\u8868\u9054\u88ab\u8b49\u5be6\u80fd\u589e\u52a0\u6a39\u7a81\u68d8\u5bc6\u5ea6\u4e26\u589e\u5f37\u7a81\u89f8\u5206\u5316\uff0c\u9019\u63d0\u793a\u5176\u5728\u795e\u7d93\u53ef\u5851\u6027\u4e2d\u626e\u6f14\u95dc\u9375\u89d2\u8272 <sup>49<\/sup>\u3002PGC-1\u03b1\u7684\u8868\u9054\u53d7\u591a\u7a2e\u56e0\u7d20\u8abf\u7bc0\uff0c\u5305\u62ec\u904b\u52d5\u3001\u98e2\u9913\u548c\u5bd2\u51b7\u7b49\u4ee3\u8b1d\u9700\u6c42\u4fe1\u865f <sup>24<\/sup>\u3002\u6a21\u578b\u8072\u7a31PGC-1\u03b1\u80fd\u300c\u6301\u7e8c\u8868\u9054 &gt;8 \u5468\u9577\u6548\u795e\u7d93\u53ef\u5851\u6027\u91cd\u5efa\u300d\uff0c\u9019\u662f\u4e00\u500b\u5f37\u6709\u529b\u7684\u4e3b\u5f35\u3002\u96d6\u7136PGC-1\u03b1\u5728\u795e\u7d93\u53ef\u5851\u6027\u4e2d\u7684\u4f5c\u7528\u5f97\u5230\u652f\u6301 <sup>49<\/sup>\uff0c\u4f46\u5176\u5728\u4eba\u9ad4\u4e2d\u300c\u6301\u7e8c\u8868\u9054 &gt;8 \u5468\u300d\u4e26\u5c0e\u81f4\u300c\u9577\u6548\u795e\u7d93\u53ef\u5851\u6027\u91cd\u5efa\u300d\u7684\u76f4\u63a5\u8b49\u64da\uff0c\u5728\u6240\u63d0\u4f9b\u7684\u8cc7\u6599\u4e2d\u4e26\u672a\u660e\u78ba\u95e1\u8ff0\u3002\u9019\u4ee3\u8868\u4e86\u4e2d\u85e5\u5728\u63d0\u4f9b\u66f4\u6301\u4e45\u7684\u5206\u5b50\u5c64\u9762\u6539\u5584\u65b9\u9762\u7684\u6f5b\u5728\u512a\u52e2\uff0c\u4f46\u4ecd\u9700\u66f4\u6df1\u5165\u7684\u9577\u671f\u7814\u7a76\u3002<\/p>\n\n\n\n<p><strong>\u7b2c\u56db\u7ae0\uff1a\u81e8\u5e8a\u8f49\u5316\u61c9\u7528\u65b9\u6848<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u6240\u63d0\u51fa\u7684\u81e8\u5e8a\u8f49\u5316\u65b9\u6848\u5c07\u4e2d\u85e5\u65b9\u5291\u8207\u5206\u5b50\u76ee\u6a19\u53ca\u76e3\u6e2c\u6307\u6a19\u76f8\u7d50\u5408\uff0c\u65e8\u5728\u63d0\u4f9b\u5206\u968e\u6bb5\u7684\u6cbb\u7642\u7b56\u7565\u3002<\/p>\n\n\n\n<p><strong>\u6025\u6027\u671f\u5e72\u9810\uff08<\/strong><strong>1-2<\/strong><strong>\u5468\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>\u65b9\u5291\uff1a\u67f4\u80e1<\/strong><strong> 12g + <\/strong><strong>\u6894\u5b50<\/strong><strong> 9g + <\/strong><strong>\u9178\u68d7\u4ec1<\/strong><strong> 15g + <\/strong><strong>\u725b\u819d<\/strong><strong> 10g<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u6b64\u65b9\u5291\u65e8\u5728\u6025\u6027\u671f\u5feb\u901f\u7de9\u89e3\u708e\u75c7\u3001\u555f\u52d5\u795e\u7d93\u4fee\u5fa9\u4e26\u7a69\u5b9a\u60c5\u7dd2\u3002<\/p>\n\n\n\n<p><strong>\u5206\u5b50\u76ee\u6a19\uff1a<\/strong><strong>72 <\/strong><strong>\u5c0f\u6642\u964d\u4f4e<\/strong><strong> <\/strong><strong>\u8840\u6e05<\/strong><strong> IL-6 \u2265 40%<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c72 \u5c0f\u6642\u964d\u4f4e \u8840\u6e05 IL-6 \u2265 40%\u300d\u3002<\/p>\n\n\n\n<p>\u708e\u75c7\u7d30\u80de\u56e0\u5b50IL-6\u88ab\u8b49\u5be6\u8207\u6291\u9b31\u75c7\u72c0\u7684\u56b4\u91cd\u7a0b\u5ea6\u76f8\u95dc\uff0c\u4e14\u6297\u708e\u85e5\u7269\u5728\u6291\u9b31\u75c7\u6cbb\u7642\u4e2d\u986f\u793a\u51fa\u6f5b\u5728\u6548\u679c <sup>3<\/sup>\u3002\u67f4\u80e1\u5177\u6709\u964d\u4f4eTNF-\u03b1\u7684\u6297\u708e\u4f5c\u7528 <sup>32<\/sup>\uff0c\u800c\u6894\u5b50\u4e5f\u5177\u6709\u6297\u708e\u6d3b\u6027 <sup>39<\/sup>\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599\u4e2d\uff0c\u95dc\u65bc\u5728\u300c72\u5c0f\u6642\u5167\u5c07\u8840\u6e05IL-6\u964d\u4f4e\u226540%\u300d\u9019\u4e00\u5177\u9ad4\u76ee\u6a19\uff0c\u4e26\u672a\u76f4\u63a5\u4f86\u81ea\u91dd\u5c0d\u9019\u4e9b\u4e2d\u85e5\u7684\u81e8\u5e8a\u8a66\u9a57\u3002\u6709\u81e8\u5e8a\u8a66\u9a57\u6b63\u5728\u7814\u7a76IL-6\u5728\u6291\u9b31\u75c7\u4e2d\u7684\u4f5c\u7528\uff0c\u4e26\u4f7f\u7528\u6258\u73e0\u55ae\u6297\uff08\u4e00\u7a2eIL-6\u4fe1\u865f\u6291\u5236\u5291\u85e5\u7269\uff09\uff0c\u4f46\u8a72\u7814\u7a76\u4e26\u672a\u6d89\u53ca\u4e2d\u85e5\uff0c\u4e5f\u672a\u63d0\u4f9b\u4e2d\u85e5\u572872\u5c0f\u6642\u5167\u9054\u523040%\u964d\u4f4e\u7684\u6578\u64da <sup>64<\/sup>\u3002\u56e0\u6b64\uff0c\u8a72\u5206\u5b50\u76ee\u6a19\u96d6\u7136\u65b9\u5411\u6b63\u78ba\uff0c\u4f46\u5176\u5177\u9ad4\u91cf\u5316\u548c\u6642\u9593\u6846\u67b6\uff0c\u5c0d\u65bc\u6240\u63d0\u51fa\u7684\u4e2d\u85e5\u65b9\u5291\u800c\u8a00\uff0c\u4ecd\u7f3a\u4e4f\u76f4\u63a5\u7684\u81e8\u5e8a\u5be6\u8b49\u652f\u6301\u3002<\/p>\n\n\n\n<p><strong>\u5206\u5b50\u76ee\u6a19\uff1a<\/strong><strong>7 <\/strong><strong>\u5929\u63d0\u5347<\/strong><strong> <\/strong><strong>\u8840\u6f3f<\/strong><strong> BDNF &gt; 30%<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c7 \u5929\u63d0\u5347 \u8840\u6f3f BDNF &gt; 30%\u300d\u3002<\/p>\n\n\n\n<p>BDNF\u6c34\u5e73\u8207\u6291\u9b31\u75c7\u7684\u767c\u751f\u548c\u9032\u5c55\u5bc6\u5207\u76f8\u95dc\uff0c\u6297\u6291\u9b31\u6cbb\u7642\u53ef\u6062\u5fa9BDNF\u6c34\u5e73 <sup>38<\/sup>\u3002\u9060\u5fd7\u5df2\u88ab\u8b49\u5be6\u80fd\u5feb\u901f\u555f\u52d5BDNF-TrkB\u901a\u8def <sup>36<\/sup>\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599\u4e2d\uff0c\u4e26\u7121\u91dd\u5c0d\u6240\u63d0\u51fa\u4e2d\u85e5\u65b9\u5291\u5728\u300c7\u5929\u5167\u5c07\u8840\u6f3fBDNF\u63d0\u5347&gt;30%\u300d\u7684\u76f4\u63a5\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\u3002\u6709\u7814\u7a76\u986f\u793a\uff0c\u51a5\u60f3\u8a13\u7df4\u5728\u5065\u5eb7\u6210\u4eba\u4e2d\u53ef\u5c0e\u81f4BDNF\u57283\u30016\u30019\u500b\u6708\u5f8c\u7d2f\u7a4d\u6027\u589e\u52a0\uff0c\u4f46\u9019\u4e26\u975e7\u5929\u5167\u9054\u523030%\u7684\u63d0\u5347 <sup>57<\/sup>\u3002\u5176\u4ed6\u81e8\u5e8a\u8a66\u9a57\u4e2dBDNF\u7684\u8b8a\u5316\u901a\u5e38\u5728\u66f4\u9577\u7684\u6642\u9593\u5c3a\u5ea6\u4e0a\u9032\u884c\u8a55\u4f30 <sup>65<\/sup>\u3002\u56e0\u6b64\uff0c\u8a72\u5206\u5b50\u76ee\u6a19\u5728\u6642\u9593\u548c\u91cf\u5316\u4e0a\u986f\u5f97\u6975\u70ba\u6fc0\u9032\uff0c\u7f3a\u4e4f\u76f4\u63a5\u7684\u81e8\u5e8a\u5be6\u8b49\u652f\u6301\u3002<\/p>\n\n\n\n<p><strong>\u978f\u56fa\u671f\u8abf\u7bc0\uff08<\/strong><strong>2-6<\/strong><strong>\u6708\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>\u65b9\u5291\uff1a\u828d\u85e5<\/strong><strong> 12g + <\/strong><strong>\u9060\u5fd7<\/strong><strong> 6g + <\/strong><strong>\u9ec3\u67cf<\/strong><strong> 6g + <\/strong><strong>\u9f8d\u9aa8<\/strong><strong> 30g<\/strong><strong>\uff08\u5148\u714e\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u6b64\u65b9\u5291\u65e8\u5728\u978f\u56fa\u6025\u6027\u671f\u7642\u6548\uff0c\u4fc3\u9032\u9577\u671f\u7a69\u5b9a\u3002<\/p>\n\n\n\n<p><strong>\u76e3\u6e2c\u6307\u6a19\uff1a\u553e\u6db2\u76ae\u8cea\u9187\u665d\u591c\u7bc0\u5f8b\uff08\u6062\u5fa9\u6668\u9ad8\u591c\u4f4e\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u553e\u6db2\u76ae\u8cea\u9187\u665d\u591c\u7bc0\u5f8b\uff08\u6062\u5fa9\u6668\u9ad8\u591c\u4f4e\uff09\u300d\u3002<\/p>\n\n\n\n<p>\u553e\u6db2\u76ae\u8cea\u9187\u665d\u591c\u7bc0\u5f8b\u662f\u8a55\u4f30HPA\u8ef8\u529f\u80fd\u548c\u61c9\u6fc0\u53cd\u61c9\u7684\u91cd\u8981\u751f\u7269\u6a19\u8a8c\u7269\uff0c\u5728\u6291\u9b31\u75c7\u60a3\u8005\u4e2d\u5e38\u8868\u73fe\u51fa\u665d\u591c\u7bc0\u5f8b\u7d0a\u4e82 <sup>66<\/sup>\u3002\u76e3\u6e2c\u76ae\u8cea\u9187\u7bc0\u5f8b\u7684\u6062\u5fa9\uff0c\u662f\u8a55\u4f30\u6cbb\u7642\u6548\u679c\u548c\u751f\u7406\u5e73\u8861\u91cd\u5efa\u7684\u5408\u7406\u81e8\u5e8a\u6307\u6a19\u3002<\/p>\n\n\n\n<p><strong>\u76e3\u6e2c\u6307\u6a19\uff1a<\/strong><strong>fMRI <\/strong><strong>\u6d77\u99ac\u9ad4\u7a4d\u8b8a\u5316\uff08\u6bcf\u6708\u589e\u9577<\/strong><strong> \u2265 1.5%<\/strong><strong>\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300cfMRI \u6d77\u99ac\u9ad4\u7a4d\u8b8a\u5316\uff08\u6bcf\u6708\u589e\u9577 \u2265 1.5%\uff09\u300d\u3002<\/p>\n\n\n\n<p>\u6d77\u99ac\u9ad4\u7a4d\u7684\u8b8a\u5316\u8207\u6291\u9b31\u75c7\u76f8\u95dc\uff0c\u4e14\u6297\u6291\u9b31\u6cbb\u7642\u53ef\u80fd\u5f71\u97ff\u6d77\u99ac\u9ad4\u7a4d <sup>67<\/sup>\u3002fMRI\uff08\u529f\u80fd\u6027\u78c1\u5171\u632f\u6210\u50cf\uff09\u53ef\u7528\u65bc\u76e3\u6e2c\u6d77\u99ac\u9ad4\u7a4d\u7684\u8b8a\u5316 <sup>65<\/sup>\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599\u4e2d\uff0c<strong>\u6c92\u6709\u76f4\u63a5\u8b49\u64da\u652f\u6301\u300c\u6bcf\u6708\u589e\u9577<\/strong><strong>\u22651.5%<\/strong><strong>\u300d\u9019\u4e00\u5177\u9ad4\u7684\u6d77\u99ac\u9ad4\u7a4d\u589e\u9577\u7387<\/strong>\u3002\u73fe\u6709\u7814\u7a76\u8a0e\u8ad6\u6d77\u99ac\u9ad4\u7a4d\u7684\u8b8a\u5316\u901a\u5e38\u5728\u6578\u6708\u751a\u81f3\u6578\u5e74\u7684\u6642\u9593\u5c3a\u5ea6\u4e0a\uff0c\u4e14\u5176\u589e\u9577\u7387\u4e26\u672a\u5982\u6b64\u7cbe\u78ba\u5730\u91cf\u5316 <sup>57<\/sup>\u3002\u56e0\u6b64\uff0c\u6bcf\u67081.5%\u7684\u589e\u9577\u7387\u662f\u4e00\u500b\u9ad8\u5ea6\u63a8\u6e2c\u6027\u7684\u76ee\u6a19\uff0c\u5728\u81e8\u5e8a\u5be6\u8e10\u4e2d\u5176\u53ef\u884c\u6027\u548c\u53ef\u91cf\u5316\u6027\u4ecd\u9700\u56b4\u8b39\u7684\u9a57\u8b49\u3002<\/p>\n\n\n\n<p><strong>\u9810\u9632\u5fa9\u767c\u6a5f\u5236<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>\u8868\u89c0\u907a\u50b3\u8abf\u63a7\uff1a\u67f4\u80e1\u7682\u82f7\u8a98\u5c0e<\/strong><strong> GAD67 <\/strong><strong>\u57fa\u56e0\u53bb\u7532\u57fa\u5316<\/strong><strong> \u2192 <\/strong><strong>\u7d42\u8eab\u63d0\u5347<\/strong><strong> GABA <\/strong><strong>\u5408\u6210\u80fd\u529b<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u8868\u89c0\u907a\u50b3\u8abf\u63a7\uff1a\u67f4\u80e1\u7682\u82f7\u8a98\u5c0e GAD67 \u57fa\u56e0\u53bb\u7532\u57fa\u5316 \u2192 \u7d42\u8eab\u63d0\u5347 GABA \u5408\u6210\u80fd\u529b\uff08Epigenetics. 2025\uff09\u300d\u3002<\/p>\n\n\n\n<p>GAD67\u662fGABA\u5408\u6210\u7684\u9650\u901f\u9176\uff0c\u5c0d\u65bc\u7dad\u6301\u57fa\u790eGABA\u6c34\u5e73\u81f3\u95dc\u91cd\u8981 <sup>21<\/sup>\u3002\u67f4\u80e1\u542b\u6709\u4e09\u841c\u7682\u82f7\uff08\u5982\u67f4\u80e1\u7682\u82f7\uff09 <sup>32<\/sup>\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u5728\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599\u4e2d\uff0c<strong>\u6c92\u6709\u76f4\u63a5\u8b49\u64da\u8868\u660e\u67f4\u80e1\u7682\u82f7\u80fd\u5920\u8a98\u5c0e<\/strong><strong>GAD67<\/strong><strong>\u57fa\u56e0\u53bb\u7532\u57fa\u5316\uff0c\u66f4\u6c92\u6709\u8b49\u64da\u652f\u6301\u5176\u80fd\u5c0e\u81f4\u300c\u7d42\u8eab\u63d0\u5347<\/strong><strong>GABA<\/strong><strong>\u5408\u6210\u80fd\u529b\u300d<\/strong>\u3002\u96d6\u7136\u8868\u89c0\u907a\u50b3\u8abf\u63a7\u662f\u795e\u7d93\u7cbe\u795e\u75be\u75c5\u7814\u7a76\u7684\u71b1\u9ede\uff0c\u4e14\u4e2d\u85e5\u53ef\u80fd\u5f71\u97ff\u57fa\u56e0\u8868\u9054\uff0c\u4f46\u6b64\u8655\u7684\u8072\u7a31\u7f3a\u4e4f\u76f4\u63a5\u7684\u5206\u5b50\u751f\u7269\u5b78\u8b49\u64da\u652f\u6301\u3002\u539f\u59cb\u6a21\u578b\u4e2d\u5f15\u7528\u7684\u300cEpigenetics. 2025\u300d\u70ba\u672a\u4f86\u5e74\u4efd\u7684\u6587\u737b\uff0c\u7121\u6cd5\u9a57\u8b49\u3002\u56e0\u6b64\uff0c\u8a72\u6a5f\u5236\u662f\u4e00\u500b\u9ad8\u5ea6\u63a8\u6e2c\u6027\u7684\u4e3b\u5f35\uff0c\u9700\u8981\u5927\u91cf\u7684\u57fa\u790e\u7814\u7a76\u4f86\u8b49\u5be6\u3002<\/p>\n\n\n\n<p><strong>\u7dda\u7c92\u9ad4\u907a\u7522\u6548\u61c9\uff1a\u725b\u819d\u555f\u52d5<\/strong><strong> mtDNA <\/strong><strong>\u4fee\u5fa9\u9176<\/strong><strong> OGG1 \u2192 <\/strong><strong>\u6e1b\u5c11\u6c27\u5316\u640d\u50b7\u7d2f\u7a4d<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u539f\u59cb\u6a21\u578b\u8072\u7a31\uff1a\u300c\u7dda\u7c92\u9ad4\u907a\u7522\u6548\u61c9\uff1a\u725b\u819d\u555f\u52d5 mtDNA \u4fee\u5fa9\u9176 OGG1 \u2192 \u6e1b\u5c11\u6c27\u5316\u640d\u50b7\u7d2f\u7a4d\u300d\u3002<\/p>\n\n\n\n<p>OGG1\uff088-\u6c27\u9ce5\u560c\u5464DNA\u7cd6\u82f7\u9176\uff09\u662f\u4e00\u7a2eDNA\u4fee\u5fa9\u86cb\u767d\uff0c\u53c3\u8207\u5f9e\u6838\u9178\u93c8\uff08\u5305\u62ecmtDNA\uff09\u4e2d\u5207\u9664\u6c27\u5316\u9ce5\u560c\u5464\u9e7c\u57fa <sup>25<\/sup>\u3002\u5c07hOGG1\u9776\u5411\u7dda\u7c92\u9ad4\u53ef\u4fdd\u8b77\u7d30\u80de\u514d\u53d7mtDNA\u640d\u50b7\u4e26\u589e\u52a0\u7dda\u7c92\u9ad4\u529f\u80fd <sup>25<\/sup>\u3002\u725b\u819d\uff08Achyranthes bidentata\uff09\u88ab\u63d0\u53ca\u80fd\u5920\u4fdd\u8b77\u7dda\u7c92\u9ad4\u514d\u53d7\u6c27\u5316\u7206\u767c\u4e26\u9632\u6b62ATP\u640d\u5931 <sup>75<\/sup>\u3002<\/p>\n\n\n\n<p>\u5118\u7ba1\u725b\u819d\u5728\u7dda\u7c92\u9ad4\u4fdd\u8b77\u65b9\u9762\u6709\u6f5b\u529b\uff0c\u4e14OGG1\u5728mtDNA\u4fee\u5fa9\u4e2d\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c\u4f46\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599\u4e2d\uff0c<strong>\u6c92\u6709\u76f4\u63a5\u8b49\u64da\u8868\u660e\u725b\u819d\u80fd\u5920\u7279\u7570\u6027\u5730\u300c\u555f\u52d5<\/strong><strong>mtDNA<\/strong><strong>\u4fee\u5fa9\u9176<\/strong><strong>OGG1<\/strong><strong>\u300d<\/strong>\u3002\u9019\u7a2e\u9023\u7d50\u662f\u63a8\u65b7\u6027\u7684\uff0c\u800c\u975e\u76f4\u63a5\u7684\u5be6\u9a57\u8b49\u5be6\u3002\u56e0\u6b64\uff0c\u61c9\u4fee\u6b63\u70ba\uff1a\u725b\u819d\u53ef\u80fd\u900f\u904e\u5176\u6297\u6c27\u5316\u548c\u7dda\u7c92\u9ad4\u4fdd\u8b77\u4f5c\u7528\uff0c\u9593\u63a5\u6709\u52a9\u65bc\u6e1b\u5c11\u6c27\u5316\u640d\u50b7\u7684\u7d2f\u7a4d\uff0c\u4f46\u5176\u662f\u5426\u76f4\u63a5\u555f\u52d5mtDNA\u4fee\u5fa9\u9176OGG1\u4ecd\u9700\u9032\u4e00\u6b65\u7684\u5206\u5b50\u6a5f\u5236\u7814\u7a76\u3002<\/p>\n\n\n\n<p><strong>\u7b2c\u4e94\u7ae0\uff1a\u8eab\u5fc3\u6574\u5408\u6cbb\u7642\u7684\u79d1\u5b78\u7bc4\u5f0f<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u6240\u63d0\u51fa\u7684\u300c\u7761\u7720-\u80fd\u91cf\u8abf\u63a7\u6a21\u578b\u300d\u65e8\u5728\u69cb\u5efa\u4e00\u500b\u5168\u9762\u7684\u8eab\u5fc3\u6574\u5408\u6cbb\u7642\u7bc4\u5f0f\uff0c\u5c07\u751f\u7269\u5b78\u5e72\u9810\u8207\u5fc3\u7406\u5b78\u7b56\u7565\u76f8\u7d50\u5408\u3002<\/p>\n\n\n\n<p>\u8a72\u7bc4\u5f0f\u5f37\u8abf\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u8eab<\/strong><strong>[<\/strong><strong>\u751f\u7269\u5b78\u5c64\u9762<\/strong><strong>] &#8211;> <\/strong><strong>\u7dda\u7c92\u9ad4\u4fee\u5fa9<\/strong><strong>\/<\/strong><strong>\u6297\u708e<\/strong><strong>\/<\/strong><strong>\u795e\u7d93\u53ef\u5851\u6027<\/strong>\uff1a\u900f\u904e\u91dd\u5c0d\u80fd\u91cf\u4ee3\u8b1d\u5d29\u6f70\u3001\u795e\u7d93\u708e\u75c7\u548c\u795e\u7d93\u53ef\u5851\u6027\u7f3a\u9677\u7684\u5206\u5b50\u5e72\u9810\uff0c\u6062\u5fa9\u751f\u7269\u5b78\u57fa\u790e\u529f\u80fd\u3002<\/li>\n\n\n\n<li><strong>\u5fc3<\/strong><strong>[<\/strong><strong>\u5fc3\u7406\u5c64\u9762<\/strong><strong>] &#8211;> <\/strong><strong>\u6b63\u5ff5\u8a13\u7df4\u589e\u5f37\u524d\u984d\u8449\u8abf\u63a7<\/strong>\uff1a\u5fc3\u7406\u5e72\u9810\uff0c\u5982\u6b63\u5ff5\u8a13\u7df4\uff0c\u53ef\u589e\u5f37\u524d\u984d\u8449\u76ae\u5c64\u5c0d\u60c5\u7dd2\u548c\u8a8d\u77e5\u7684\u8abf\u63a7\u80fd\u529b <sup>57<\/sup>\u3002\u7814\u7a76\u986f\u793a\uff0c\u51a5\u60f3\u8a13\u7df4\u53ef\u589e\u52a0BDNF\u4e26\u964d\u4f4e\u76ae\u8cea\u9187\uff0c\u9019\u8207\u6d77\u99ac\u9ad4\u7a4d\u7684\u589e\u52a0\u76f8\u95dc <sup>57<\/sup>\u3002<\/li>\n\n\n\n<li><strong>\u8eab<\/strong><strong> &amp; <\/strong><strong>\u5fc3<\/strong><strong> &#8211;> <\/strong><strong>\u80fd\u91cf<\/strong><strong>&#8211;<\/strong><strong>\u795e\u7d93<\/strong><strong>&#8211;<\/strong><strong>\u514d\u75ab\u7db2\u8def\u518d\u5e73\u8861<\/strong>\uff1a\u751f\u7269\u5b78\u548c\u5fc3\u7406\u5b78\u5e72\u9810\u7684\u7d50\u5408\uff0c\u65e8\u5728\u5be6\u73fe\u80fd\u91cf\u3001\u795e\u7d93\u548c\u514d\u75ab\u7cfb\u7d71\u7684\u5168\u9762\u518d\u5e73\u8861\uff0c\u9019\u8207\u6291\u9b31\u75c7\u7684\u7cfb\u7d71\u6027\u75c5\u7406\u5b78\u89c0\u9ede\u4e00\u81f4 <sup>3<\/sup>\u3002<\/li>\n\n\n\n<li><strong>\u6cbb\u7642\u7d42\u9ede<\/strong>\uff1a\u6700\u7d42\u76ee\u6a19\u662f\u6062\u5fa9\u95dc\u9375\u751f\u7406\u6307\u6a19\u7684\u52d5\u614b\u5e73\u8861\uff0c\u5305\u62ecATP\/ADP\u6bd4\u503c\u7684\u665d\u591c\u7bc0\u5f8b\u548cGABA\/\u8c37\u6c28\u9178\u7684\u5e73\u8861\uff0c\u9019\u53cd\u6620\u4e86\u795e\u7d93\u5143\u6d3b\u52d5\u548c\u80fd\u91cf\u4ee3\u8b1d\u7684\u5065\u5eb7\u72c0\u614b\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u5206\u5b50\u8b49\u64da\u7e3d\u7d50<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u672c\u6a21\u578b\u5c0d\u7126\u616e\u8207\u6291\u9b31\u75c7\u7684\u5206\u5b50\u672c\u8cea\u63d0\u51fa\u4e86\u7cbe\u7149\u7684\u7e3d\u7d50\uff0c\u4e26\u5c07\u4e2d\u85e5\u7684\u6cbb\u7642\u7406\u5ff5\u8f49\u5316\u70ba\u53ef\u91cf\u5316\u7684\u5206\u5b50\u901a\u8def\u3002<\/p>\n\n\n\n<p><strong>\u7126\u616e\u672c\u8cea<\/strong><strong> = GABA <\/strong><strong>\u80fd\u6291\u5236\u7f3a\u640d<\/strong><strong> + <\/strong><strong>\u674f\u4ec1\u6838<\/strong><strong> ATP <\/strong><strong>\u4f9b\u61c9\u4e0d\u8db3<\/strong><strong> \u2192 <\/strong><strong>\u6050\u61fc\u74b0\u8def\u5931\u63a7<\/strong><strong><\/strong><\/p>\n\n\n\n<p>GABA\u80fd\u6291\u5236\u7684\u7f3a\u9677\u78ba\u5be6\u662f\u7126\u616e\u7684\u6838\u5fc3\u75c5\u7406\u4e4b\u4e00\u3002\u674f\u4ec1\u6838\u662f\u6050\u61fc\u548c\u60c5\u7dd2\u8655\u7406\u7684\u95dc\u9375\u8166\u5340\uff0c\u5176GABA\u80fd\u6291\u5236\u7684\u7834\u58de\u6703\u5c0e\u81f4\u904e\u5ea6\u8208\u596e\u548c\u7126\u616e\u6a23\u884c\u70ba <sup>1<\/sup>\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u95dc\u65bc\u300c\u674f\u4ec1\u6838ATP\u4f9b\u61c9\u4e0d\u8db3\u300d\u4f5c\u70ba\u7126\u616e\u6838\u5fc3\u7684\u76f4\u63a5\u8b49\u64da\uff0c\u5728\u6240\u63d0\u4f9b\u7684\u8cc7\u6599\u4e2d\u4e26\u672a\u660e\u78ba\u6307\u51fa\u3002\u5118\u7ba1\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u666e\u904d\u5f71\u97ffATP\u751f\u6210\u4e26\u8207\u7cbe\u795e\u75be\u75c5\u76f8\u95dc <sup>4<\/sup>\uff0c\u4f46\u5c07\u300c\u674f\u4ec1\u6838ATP\u4f9b\u61c9\u4e0d\u8db3\u300d\u76f4\u63a5\u5217\u70ba\u7126\u616e\u7684\u672c\u8cea\uff0c\u4ecd\u9700\u66f4\u5177\u9ad4\u548c\u5c40\u90e8\u7684\u5be6\u8b49\u652f\u6301\u3002\u61c9\u4fee\u6b63\u70ba\uff1a\u7126\u616e\u7684\u672c\u8cea\u53ef\u80fd\u6d89\u53caGABA\u80fd\u6291\u5236\u7684\u7f3a\u9677\uff0c\u5c0e\u81f4\u674f\u4ec1\u6838\u6050\u61fc\u74b0\u8def\u5931\u63a7\u3002\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u548c\u80fd\u91cf\u4f9b\u61c9\u4e0d\u8db3\u53ef\u80fd\u52a0\u5287\u6b64\u75c5\u7406\uff0c\u4f46\u674f\u4ec1\u6838\u7279\u7570\u6027ATP\u4f9b\u61c9\u4e0d\u8db3\u4f5c\u70ba\u6838\u5fc3\u9a45\u52d5\u56e0\u7d20\u4ecd\u9700\u66f4\u591a\u76f4\u63a5\u8b49\u64da\u3002<\/p>\n\n\n\n<p><strong>\u6291\u9b31\u6838\u5fc3<\/strong><strong> = <\/strong><strong>\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919<\/strong><strong> \u2192 <\/strong><strong>\u524d\u984d\u8449<\/strong><strong>&#8211;<\/strong><strong>\u908a\u7de3\u7cfb\u7d71\u9023\u63a5\u6e1b\u5f31\uff08<\/strong><strong>DTI <\/strong><strong>\u8b49\u5be6\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u88ab\u5ee3\u6cdb\u8a8d\u70ba\u662f\u91cd\u5ea6\u6291\u9b31\u75c7\u7684\u95dc\u9375\u75c5\u7406\u5b78\u56e0\u7d20\uff0c\u5c0e\u81f4ATP\u751f\u6210\u6e1b\u5c11\u4e26\u5f71\u97ff\u8166\u529f\u80fd <sup>4<\/sup>\u3002\u524d\u984d\u8449\u76ae\u5c64\u5728MDD\u4e2d\u6301\u7e8c\u53d7\u640d <sup>7<\/sup>\u3002<\/p>\n\n\n\n<p>\u5c07\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\u8207\u300c\u524d\u984d\u8449-\u908a\u7de3\u7cfb\u7d71\u9023\u63a5\u6e1b\u5f31\u300d\u76f4\u63a5\u806f\u7e6b\u8d77\u4f86\uff0c\u4e26\u8072\u7a31\u300cDTI\u8b49\u5be6\u300d\uff0c\u5728\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599\u4e2d\u4e26\u672a\u76f4\u63a5\u627e\u5230\u652f\u6301\u3002\u96d6\u7136DTI\uff08\u64f4\u6563\u5f35\u91cf\u6210\u50cf\uff09\u53ef\u4ee5\u8a55\u4f30\u8166\u5340\u9023\u63a5\uff0c\u4f46\u6240\u63d0\u4f9b\u7684\u8cc7\u6599\u4e26\u672a\u5305\u542bDTI\u7814\u7a76\u7684\u5177\u9ad4\u7d50\u679c\u4f86\u8b49\u5be6\u9019\u4e00\u7279\u5b9a\u9023\u7d50\u3002\u61c9\u4fee\u6b63\u70ba\uff1a\u6291\u9b31\u7684\u6838\u5fc3\u75c5\u7406\u6d89\u53ca\u7dda\u7c92\u9ad4\u529f\u80fd\u969c\u7919\uff0c\u5c0e\u81f4\u80fd\u91cf\u4ee3\u8b1d\u5931\u8861\u548c\u795e\u7d93\u5143\u529f\u80fd\u53d7\u640d\u3002\u9019\u53ef\u80fd\u9032\u4e00\u6b65\u5c0e\u81f4\u524d\u984d\u8449\u8207\u908a\u7de3\u7cfb\u7d71\u4e4b\u9593\u7684\u529f\u80fd\u9023\u63a5\u6e1b\u5f31\uff0c\u5118\u7ba1\u6b64\u9023\u63a5\u6e1b\u5f31\u7684DTI\u76f4\u63a5\u8b49\u64da\u672a\u5728\u672c\u6b21\u8cc7\u6599\u4e2d\u63d0\u4f9b\u3002<\/p>\n\n\n\n<p><strong>\u4e2d\u85e5\u667a\u6167\uff1a\u5148\u8abf\u80fd\u91cf\uff08\u725b\u819d<\/strong><strong>\/<\/strong><strong>\u9ec3\u67cf\u89e3<\/strong><strong> ATP <\/strong><strong>\u5371\u6a5f\uff09<\/strong><strong>-&gt; <\/strong><strong>\u518d\u4fee\u795e\u7d93\uff08\u828d\u85e5<\/strong><strong>\/<\/strong><strong>\u9178\u68d7\u4ec1\u91cd\u5efa<\/strong><strong> GABA<\/strong><strong>\uff09<\/strong><strong>-&gt; <\/strong><strong>\u7d42\u7a69\u5fc3\u795e\uff08\u67f4\u80e1<\/strong><strong>\/<\/strong><strong>\u6894\u5b50\u6297\u708e\u7a69\u60c5\u5fd7\uff09<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u9019\u500b\u7e3d\u7d50\u6982\u62ec\u4e86\u4e2d\u85e5\u6cbb\u7642\u7684\u5c64\u6b21\u6027\u7b56\u7565\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5148\u8abf\u80fd\u91cf\uff1a<\/strong> \u725b\u819d\uff08Achyranthes bidentata\uff09\u78ba\u5be6\u53ef\u900f\u904eAMPK-SIRT3\u901a\u8def\u6539\u5584\u7dda\u7c92\u9ad4\u529f\u80fd\u548cATP\u7522\u751f <sup>47<\/sup>\uff0c\u6709\u52a9\u65bc\u89e3\u6c7a\u80fd\u91cf\u5371\u6a5f\u3002\u7136\u800c\uff0c\u9ec3\u67cf\uff08Phellodendron amurense\uff09\u5728\u6b64\u8655\u7684\u5177\u9ad4\u4f5c\u7528\u672a\u7372\u76f4\u63a5\u8b49\u64da\u652f\u6301\u3002<\/li>\n\n\n\n<li><strong>\u518d\u4fee\u795e\u7d93\uff1a<\/strong> \u9178\u68d7\u4ec1\uff08Ziziphus jujuba\uff09\u80fd\u8abf\u7bc0GABA\u80fd\u548c\u8840\u6e05\u7d20\u80fd\u901a\u8def <sup>26<\/sup>\uff0c\u6709\u52a9\u65bcGABA\u91cd\u5efa\u3002\u7136\u800c\uff0c\u828d\u85e5\uff08Paeonia lactiflora\uff09\u5728\u6b64\u8655\u7684\u5177\u9ad4\u4f5c\u7528\u672a\u7372\u76f4\u63a5\u8b49\u64da\u652f\u6301\u3002<\/li>\n\n\n\n<li><strong>\u7d42\u7a69\u5fc3\u795e\uff1a<\/strong> \u67f4\u80e1\uff08Bupleurum chinense\uff09\u548c\u6894\u5b50\uff08Gardenia jasminoides\uff09\u5747\u5177\u6709\u6297\u708e\u4f5c\u7528 <sup>32<\/sup>\uff0c\u6709\u52a9\u65bc\u7a69\u5b9a\u60c5\u7dd2\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u6b64\u6a21\u578b\u5c07\u4e2d\u91ab\u300c\u5f62\u795e\u5408\u4e00\u300d\u7684\u601d\u60f3\u8f49\u5316\u70ba\u53ef\u91cf\u5316\u7684\u5206\u5b50\u901a\u8def\uff0c\u70ba\u60c5\u5fd7\u75c5\u63d0\u4f9b\u6839\u6cbb\u6027\u65b9\u6848\u7684\u9858\u666f\uff0c\u662f\u4e00\u500b\u5177\u6709\u524d\u77bb\u6027\u7684\u5617\u8a66\u3002\u7136\u800c\uff0c\u5982\u524d\u6240\u8ff0\uff0c\u6a21\u578b\u4e2d\u90e8\u5206\u5177\u9ad4\u91cf\u5316\u6578\u64da\u548c\u85e5\u6750-\u9776\u9ede\u9023\u7d50\u7684\u56b4\u8b39\u6027\u4ecd\u9700\u66f4\u6df1\u5165\u7684\u5be6\u8b49\u7814\u7a76\u4f86\u9a57\u8b49\u3002<\/p>\n\n\n\n<p><strong>\u7d50\u8ad6\u8207\u5efa\u8b70<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u6240\u63d0\u51fa\u7684\u300c\u7761\u7720-\u80fd\u91cf\u8abf\u63a7\u6a21\u578b\u300d\u5728\u6982\u5ff5\u4e0a\u5177\u6709\u5275\u65b0\u6027\u548c\u6f5b\u529b\uff0c\u5b83\u5617\u8a66\u5c07\u7126\u616e\u8207\u6291\u9b31\u75c7\u7684\u8907\u96dc\u75c5\u7406\u6b78\u56e0\u65bc\u80fd\u91cf\u4ee3\u8b1d\u3001GABA\u80fd\u7cfb\u7d71\u548c\u795e\u7d93\u708e\u75c7\u7b49\u591a\u7cfb\u7d71\u7684\u5931\u8861\uff0c\u4e26\u63d0\u51fa\u4e2d\u85e5\u591a\u9776\u9ede\u5e72\u9810\u7684\u6574\u5408\u65b9\u6848\u3002\u9019\u7a2e\u5f9e\u795e\u7d93\u5143\u5230\u5168\u8eab\u8abf\u7bc0\u7684\u79d1\u5b78\u6846\u67b6\uff0c\u8207\u7576\u524d\u795e\u7d93\u7cbe\u795e\u75be\u75c5\u7684\u7cfb\u7d71\u751f\u7269\u5b78\u7814\u7a76\u8da8\u52e2\u9ad8\u5ea6\u5951\u5408\uff0c\u5f37\u8abf\u4e86\u8eab\u5fc3\u6574\u5408\u6cbb\u7642\u7684\u91cd\u8981\u6027\u3002<\/p>\n\n\n\n<p>\u7136\u800c\uff0c\u672c\u5831\u544a\u7684\u5be9\u8996\u4e5f\u63ed\u793a\u4e86\u6a21\u578b\u4e2d\u5b58\u5728\u7684\u95dc\u9375\u79d1\u5b78\u4e0d\u6e96\u78ba\u548c\u8b49\u64da\u4e0d\u8db3\u4e4b\u8655\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u672a\u4f86\u5e74\u4efd\u6587\u737b\u5f15\u7528\uff1a<\/strong> \u6a21\u578b\u4e2d\u591a\u8655\u5f15\u7528\u4e86\u672a\u4f86\u5e74\u4efd\uff08\u59822024\u30012025\u5e74\uff09\u7684\u6587\u737b\uff0c\u9019\u5728\u79d1\u5b78\u5831\u544a\u4e2d\u662f\u4e0d\u6070\u7576\u7684\uff0c\u61c9\u66ff\u63db\u70ba\u5df2\u767c\u8868\u7684\u5be6\u8b49\u6578\u64da\u6216\u660e\u78ba\u6a19\u8a3b\u70ba\u9810\u671f\u7814\u7a76\u3002<\/li>\n\n\n\n<li><strong>\u5177\u9ad4\u91cf\u5316\u6578\u64da\u7f3a\u4e4f\u76f4\u63a5\u652f\u6301\uff1a<\/strong> \u8af8\u5982\u300c\u524d\u984d\u8449\u76ae\u5c64\u7dda\u7c92\u9ad4\u8907\u5408\u9ad4 I \u6d3b\u6027\u4e0b\u964d 40%\u300d\u3001\u300c\u6291\u9b31\u60a3\u8005\u6d77\u99ac\u5340 GABAA \u53d7\u9ad4 \u03b15 \u4e9e\u57fa\u8868\u9054\u6e1b\u5c11 60%\u300d\u3001\u300c\u725b\u819d\u63d0\u5347 ATP \u5408\u6210\u6548\u7387 35%\u300d\u3001\u300cIL-6 \u964d\u4f4e \u2265 40%\u300d\u3001\u300cBDNF \u63d0\u5347 > 30%\u300d\u3001\u300cfMRI \u6d77\u99ac\u9ad4\u7a4d\u6bcf\u6708\u589e\u9577 \u2265 1.5%\u300d\u7b49\u5177\u9ad4\u767e\u5206\u6bd4\u548c\u95be\u503c\uff0c\u5728\u6240\u63d0\u4f9b\u7684\u7814\u7a76\u8cc7\u6599\u4e2d\u5747\u672a\u627e\u5230\u76f4\u63a5\u4e14\u660e\u78ba\u7684\u652f\u6301\u3002\u90e8\u5206\u6578\u64da\u751a\u81f3\u8207\u73fe\u6709\u8b49\u64da\u76f8\u6096\uff08\u5982GABAA \u03b15\u4e9e\u57fa\u7684\u8868\u9054\u8b8a\u5316\uff09\u3002<\/li>\n\n\n\n<li><strong>\u90e8\u5206\u4e2d\u85e5\u6a5f\u5236\u9023\u7d50\u7684\u56b4\u8b39\u6027\u4e0d\u8db3\uff1a<\/strong> \u5118\u7ba1\u4e2d\u85e5\u5177\u6709\u5ee3\u6cdb\u7684\u751f\u7269\u6d3b\u6027\uff0c\u4f46\u6a21\u578b\u4e2d\u5c0d\u67d0\u4e9b\u85e5\u6750\uff08\u5982\u9ec3\u67cf\u3001\u828d\u85e5\u3001\u67f4\u80e1\uff09\u8207\u7279\u5b9a\u5206\u5b50\u9776\u9ede\uff08\u5982AMPK\/PGC-1\u03b1\u3001GABAA \u03b15\u4e9e\u57fa\u3001IDO\u9176\uff09\u7684\u76f4\u63a5\u6a5f\u5236\u9023\u7d50\uff0c\u5728\u73fe\u6709\u8cc7\u6599\u4e2d\u7f3a\u4e4f\u5145\u5206\u7684\u76f4\u63a5\u5be6\u8b49\u3002\u4f8b\u5982\uff0c\u67f4\u80e1\u6291\u5236IDO\u9176\u3001\u67f4\u80e1\u7682\u82f7\u8a98\u5c0eGAD67\u57fa\u56e0\u53bb\u7532\u57fa\u5316\u3001\u725b\u819d\u555f\u52d5OGG1\u7b49\uff0c\u5747\u70ba\u63a8\u6e2c\u6027\u8f03\u5f37\u7684\u6a5f\u5236\uff0c\u9700\u8981\u66f4\u6df1\u5165\u7684\u5206\u5b50\u751f\u7269\u5b78\u5be6\u9a57\u4f86\u8b49\u5be6\u3002<\/li>\n\n\n\n<li><strong>\u81e8\u5e8a\u8f49\u5316\u76ee\u6a19\u7684\u73fe\u5be6\u6027\uff1a<\/strong> \u63d0\u51fa\u7684\u6025\u6027\u671f\u548c\u978f\u56fa\u671f\u5206\u5b50\u76ee\u6a19\uff08\u598272\u5c0f\u6642IL-6\u964d\u4f4e40%\u30017\u5929BDNF\u63d0\u534730%\uff09\u4ee5\u53cafMRI\u76e3\u6e2c\u6307\u6a19\u7684\u5177\u9ad4\u589e\u9577\u7387\uff0c\u5728\u81e8\u5e8a\u5be6\u8e10\u4e2d\u6975\u5177\u6311\u6230\u6027\uff0c\u4e14\u7f3a\u4e4f\u73fe\u6709\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\u7684\u652f\u6301\u3002<\/li>\n<\/ol>\n\n\n\n<p><strong>\u57fa\u65bc\u4ee5\u4e0a\u5206\u6790\uff0c\u5efa\u8b70\u5982\u4e0b\uff1a<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4fee\u6b63\u6578\u64da\u8207\u5f15\u7528\uff1a<\/strong> \u5c0d\u6240\u6709\u91cf\u5316\u6578\u64da\u548c\u6587\u737b\u5f15\u7528\u9032\u884c\u56b4\u683c\u6821\u5c0d\uff0c\u79fb\u9664\u6216\u4fee\u6b63\u7f3a\u4e4f\u76f4\u63a5\u5be6\u8b49\u652f\u6301\u7684\u8072\u7a31\uff0c\u4e26\u66ff\u63db\u70ba\u5df2\u767c\u8868\u7684\u3001\u53ef\u9a57\u8b49\u7684\u79d1\u5b78\u6587\u737b\u3002\u5c0d\u65bc\u63a8\u6e2c\u6027\u6a5f\u5236\uff0c\u61c9\u660e\u78ba\u6307\u51fa\u5176\u4ecd\u8655\u65bc\u7814\u7a76\u968e\u6bb5\uff0c\u9700\u66f4\u591a\u5be6\u9a57\u9a57\u8b49\u3002<\/li>\n\n\n\n<li><strong>\u52a0\u5f37\u6a5f\u5236\u7814\u7a76\uff1a<\/strong> \u91dd\u5c0d\u4e2d\u85e5\u8207\u7279\u5b9a\u5206\u5b50\u9776\u9ede\u7684\u9023\u7d50\uff0c\u61c9\u6295\u5165\u66f4\u591a\u57fa\u790e\u7814\u7a76\uff0c\u900f\u904e\u9ad4\u5916\u548c\u9ad4\u5167\u5be6\u9a57\uff0c\u7cbe\u78ba\u95e1\u660e\u5176\u4f5c\u7528\u6a5f\u5236\u548c\u751f\u7269\u5b78\u6548\u61c9\u3002\u7279\u5225\u662f\u5c0d\u65bc\u8868\u89c0\u907a\u50b3\u8abf\u63a7\u548c\u7dda\u7c92\u9ad4\u4fee\u5fa9\u9176\u555f\u52d5\u7b49\u8907\u96dc\u6a5f\u5236\uff0c\u9700\u8981\u9ad8\u8cea\u91cf\u7684\u5be6\u9a57\u6578\u64da\u652f\u6301\u3002<\/li>\n\n\n\n<li><strong>\u8a2d\u8a08\u56b4\u8b39\u7684\u81e8\u5e8a\u8a66\u9a57\uff1a<\/strong> \u5728\u81e8\u5e8a\u8f49\u5316\u65b9\u9762\uff0c\u61c9\u8a2d\u8a08\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684\u81e8\u5e8a\u8a66\u9a57\uff0c\u4ee5\u9a57\u8b49\u4e2d\u85e5\u6574\u5408\u65b9\u6848\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u81e8\u5e8a\u8a66\u9a57\u7684\u5206\u5b50\u76ee\u6a19\u548c\u76e3\u6e2c\u6307\u6a19\u61c9\u57fa\u65bc\u66f4\u73fe\u5be6\u7684\u751f\u7269\u5b78\u8b8a\u5316\u7bc4\u570d\uff0c\u4e26\u78ba\u4fdd\u5176\u53ef\u6e2c\u6027\u548c\u81e8\u5e8a\u610f\u7fa9\u3002<\/li>\n\n\n\n<li><strong>\u5f37\u8abf\u8eab\u5fc3\u6574\u5408\u7684\u6574\u9ad4\u89c0\uff1a<\/strong> \u5118\u7ba1\u90e8\u5206\u5177\u9ad4\u7d30\u7bc0\u9700\u8981\u4fee\u6b63\uff0c\u4f46\u6a21\u578b\u6240\u5021\u5c0e\u7684\u300c\u8eab\u5fc3\u5408\u4e00\u300d\u3001\u5f9e\u80fd\u91cf-\u795e\u7d93-\u514d\u75ab\u7db2\u7d61\u5c64\u9762\u9032\u884c\u5e72\u9810\u7684\u6574\u9ad4\u89c0\u9ede\uff0c\u662f\u7b26\u5408\u7576\u4ee3\u795e\u7d93\u79d1\u5b78\u767c\u5c55\u8da8\u52e2\u7684\u3002\u672a\u4f86\u7684\u7814\u7a76\u61c9\u7e7c\u7e8c\u63a2\u7d22\u751f\u7269\u5b78\u5e72\u9810\u8207\u5fc3\u7406\u793e\u6703\u5e72\u9810\uff08\u5982\u6b63\u5ff5\u8a13\u7df4\uff09\u7684\u5354\u540c\u4f5c\u7528\uff0c\u4ee5\u671f\u70ba\u7126\u616e\u8207\u6291\u9b31\u75c7\u60a3\u8005\u63d0\u4f9b\u66f4\u5168\u9762\u3001\u66f4\u6301\u4e45\u7684\u6cbb\u7642\u65b9\u6848\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u7e3d\u9ad4\u800c\u8a00\uff0c\u8a72\u300c\u7761\u7720-\u80fd\u91cf\u8abf\u63a7\u6a21\u578b\u300d\u70ba\u7406\u89e3\u548c\u6cbb\u7642\u7126\u616e\u8207\u6291\u9b31\u75c7\u63d0\u4f9b\u4e86\u5bcc\u6709\u555f\u767c\u6027\u7684\u65b0\u8996\u89d2\uff0c\u4f46\u5176\u79d1\u5b78\u56b4\u8b39\u6027\u9700\u5927\u5e45\u63d0\u5347\uff0c\u5c24\u5176\u662f\u5728\u5177\u9ad4\u5206\u5b50\u6a5f\u5236\u548c\u91cf\u5316\u9810\u671f\u65b9\u9762\uff0c\u4ecd\u6709\u5f85\u66f4\u7d2e\u5be6\u7684\u5be6\u8b49\u7814\u7a76\u4f86\u586b\u5145\u548c\u5b8c\u5584\u3002<\/p>\n\n\n\n<p><strong>\u5f15\u7528\u7684\u8457\u4f5c<\/strong><strong><\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>GAD67 and GABA immunoreactivity (IR) in the amygdala of HAB and NAB&#8230; &#8211; ResearchGate, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.researchgate.net\/figure\/GAD67-and-GABA-immunoreactivity-IR-in-the-amygdala-of-HAB-and-NAB-mice-A-Bright_fig2_50987559\" target=\"_blank\" rel=\"noopener\">https:\/\/www.researchgate.net\/figure\/GAD67-and-GABA-immunoreactivity-IR-in-the-amygdala-of-HAB-and-NAB-mice-A-Bright_fig2_50987559<\/a><\/li>\n\n\n\n<li>Herba Rhodiolae alleviates depression via the BDNF\/TrkB-GSK-3\u03b2 signaling pathway, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/atm.amegroups.org\/article\/view\/85909\/html\" target=\"_blank\" rel=\"noopener\">https:\/\/atm.amegroups.org\/article\/view\/85909\/html<\/a><\/li>\n\n\n\n<li>Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories &#8211; Frontiers, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.frontiersin.org\/journals\/psychiatry\/articles\/10.3389\/fpsyt.2023.1130989\/full\" target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/journals\/psychiatry\/articles\/10.3389\/fpsyt.2023.1130989\/full<\/a><\/li>\n\n\n\n<li>Different Effects of SSRIs, Bupropion, and Trazodone on Mitochondrial Functions and Monoamine Oxidase Isoform Activity &#8211; PMC, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10294837\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10294837\/<\/a><\/li>\n\n\n\n<li>Mitochondria in depression: The dysfunction of mitochondrial energy metabolism and quality control systems &#8211; PMC, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10853899\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10853899\/<\/a><\/li>\n\n\n\n<li>Connecting Dots between Mitochondrial Dysfunction and Depression &#8211; MDPI, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.mdpi.com\/2218-273X\/13\/4\/695\" target=\"_blank\" rel=\"noopener\">https:\/\/www.mdpi.com\/2218-273X\/13\/4\/695<\/a><\/li>\n\n\n\n<li>Prefrontal cortex and depression &#8211; PMC &#8211; PubMed Central, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8617037\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8617037\/<\/a><\/li>\n\n\n\n<li>Psychosocial experiences are associated with human brain mitochondrial biology &#8211; PNAS, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2317673121\" target=\"_blank\" rel=\"noopener\">https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2317673121<\/a><\/li>\n\n\n\n<li>Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety &#8211; Frontiers, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.frontiersin.org\/journals\/psychiatry\/articles\/10.3389\/fpsyt.2014.00067\/full\" target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/journals\/psychiatry\/articles\/10.3389\/fpsyt.2014.00067\/full<\/a><\/li>\n\n\n\n<li>Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety &#8211; ResearchGate, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.researchgate.net\/publication\/263585019_Overexpression_of_Adenosine_A2A_Receptors_in_Rats_Effects_on_Depression_Locomotion_and_Anxiety\" target=\"_blank\" rel=\"noopener\">https:\/\/www.researchgate.net\/publication\/263585019_Overexpression_of_Adenosine_A2A_Receptors_in_Rats_Effects_on_Depression_Locomotion_and_Anxiety<\/a><\/li>\n\n\n\n<li>Adenosine through the A2A adenosine receptor increases IL-1\u03b2 in the brain contributing to anxiety &#8211; PubMed, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24907587\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/24907587\/<\/a><\/li>\n\n\n\n<li>Adenosine A2A receptor (A2AR) stimulation enhances mitochondrial metabolism and mitigates reactive oxygen species-mediated mitochondrial injury &#8211; PubMed, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32052890\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32052890\/<\/a><\/li>\n\n\n\n<li>\u0391lpha 5 subunit-containing GABAA receptors in temporal lobe epilepsy with normal MRI, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7811756\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7811756\/<\/a><\/li>\n\n\n\n<li>Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases &#8211; PMC &#8211; PubMed Central, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6103381\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6103381\/<\/a><\/li>\n\n\n\n<li>GABA &#8211; Wikipedia, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/en.wikipedia.org\/wiki\/GABA\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/GABA<\/a><\/li>\n\n\n\n<li>The GABAergic Deficit Hypothesis of Major Depressive Disorder &#8211; PMC &#8211; PubMed Central, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3412149\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3412149\/<\/a><\/li>\n\n\n\n<li>GABAA RECEPTORS AS TARGETS FOR TREATING AFFECTIVE AND COGNTIVE SYMPTOMS OF DEPRESSION &#8211; PMC &#8211; PubMed Central, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10511219\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10511219\/<\/a><\/li>\n\n\n\n<li>Input-Specific Synaptic Location and Function of the \u03b15 GABAA Receptor Subunit in the Mouse CA1 Hippocampal Neurons, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6382980\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6382980\/<\/a><\/li>\n\n\n\n<li>Negative allosteric modulation of GABAARs at \u03b15 subunit-containing benzodiazepine sites reverses stress-induced anhedonia and weakened synaptic function in mice, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9198111\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9198111\/<\/a><\/li>\n\n\n\n<li>Neurobiology and Therapeutic Potential of \u03b15-GABA Type A Receptors &#8211; Frontiers, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.frontiersin.org\/journals\/molecular-neuroscience\/articles\/10.3389\/fnmol.2019.00179\/full\" target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/journals\/molecular-neuroscience\/articles\/10.3389\/fnmol.2019.00179\/full<\/a><\/li>\n\n\n\n<li>Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase | PNAS, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.96.4.1698\" target=\"_blank\" 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rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10215733\/<\/a><\/li>\n\n\n\n<li>Mitochondrial DNA repair through OGG1 activity attenuates breast cancer progression and metastasis &#8211; PMC, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4703513\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4703513\/<\/a><\/li>\n\n\n\n<li>Regulation of GABAA and 5-HT Receptors Involved in Anxiolytic Mechanisms of Jujube Seed: A System Biology Study Assisted by UPLC-Q-TOF\/MS and RT-qPCR Method &#8211; ResearchGate, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.researchgate.net\/publication\/346218220_Regulation_of_GABAA_and_5-HT_Receptors_Involved_in_Anxiolytic_Mechanisms_of_Jujube_Seed_A_System_Biology_Study_Assisted_by_UPLC-Q-TOFMS_and_RT-qPCR_Method\" target=\"_blank\" 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target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/journals\/cardiovascular-medicine\/articles\/10.3389\/fcvm.2024.1406856\/full<\/a><\/li>\n\n\n\n<li>Tryptophan Metabolism Through the Kynurenine Pathway in Glial Cells &#8211; MDPI, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.mdpi.com\/2571-6980\/6\/1\/14\" target=\"_blank\" rel=\"noopener\">https:\/\/www.mdpi.com\/2571-6980\/6\/1\/14<\/a><\/li>\n\n\n\n<li>Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies &#8211; Frontiers, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2020.01185\/full\" target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2020.01185\/full<\/a><\/li>\n\n\n\n<li>Indoleamine 2,3-Dioxygenase (IDO) Activity: A Perspective Biomarker for Laboratory Determination in Tumor Immunotherapy &#8211; MDPI, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.mdpi.com\/2227-9059\/11\/7\/1988\" target=\"_blank\" rel=\"noopener\">https:\/\/www.mdpi.com\/2227-9059\/11\/7\/1988<\/a><\/li>\n\n\n\n<li>Bupleurum falcatum &#8211; Restorative Medicine, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/restorativemedicine.org\/library\/monographs\/bupleurum-falcatum\/\" target=\"_blank\" rel=\"noopener\">https:\/\/restorativemedicine.org\/library\/monographs\/bupleurum-falcatum\/<\/a><\/li>\n\n\n\n<li>Bupleurum in Treatment of Depression Disorder: A Comprehensive Review &#8211; MDPI, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.mdpi.com\/1424-8247\/17\/4\/512\" target=\"_blank\" rel=\"noopener\">https:\/\/www.mdpi.com\/1424-8247\/17\/4\/512<\/a><\/li>\n\n\n\n<li>Hippocampal Neurogenesis in Alzheimer&#8217;s Disease: Multimodal Therapeutics and the Neurogenic Impairment Index Framework &#8211; ResearchGate, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.researchgate.net\/publication\/393083430_Hippocampal_Neurogenesis_in_Alzheimer&#039;s_Disease_Multimodal_Therapeutics_and_the_Neurogenic_Impairment_Index_Framework\" target=\"_blank\" rel=\"noopener\">https:\/\/www.researchgate.net\/publication\/393083430_Hippocampal_Neurogenesis_in_Alzheimer&#8217;s_Disease_Multimodal_Therapeutics_and_the_Neurogenic_Impairment_Index_Framework<\/a><\/li>\n\n\n\n<li>The antidepressant-like effects of the water extract of Panax ginseng and Polygala tenuifolia are mediated via the BDNF-TrkB signaling pathway and neurogenesis in the hippocampus &#8211; PubMed, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33248184\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/33248184\/<\/a><\/li>\n\n\n\n<li>Preclinical Evidence of Rapid-Onset Antidepressant-Like Effect in Radix Polygalae Extract, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0088617\" target=\"_blank\" rel=\"noopener\">https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0088617<\/a><\/li>\n\n\n\n<li>The Antidepressant-Like Effects of Shen Yuan in a Chronic Unpredictable Mild Stress Rat Model &#8211; Frontiers, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.frontiersin.org\/journals\/psychiatry\/articles\/10.3389\/fpsyt.2021.622204\/full\" target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/journals\/psychiatry\/articles\/10.3389\/fpsyt.2021.622204\/full<\/a><\/li>\n\n\n\n<li>BDNF Unveiled: Exploring Its Role in Major Depression Disorder Serotonergic Imbalance and Associated Stress Conditions &#8211; PubMed Central, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10457827\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10457827\/<\/a><\/li>\n\n\n\n<li>Gardenia jasminoides extract and its constituent, genipin, inhibit activation of CD3\/CD28 co-stimulated CD4+ T cells via ORAI1 channel &#8211; PMC, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7317176\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7317176\/<\/a><\/li>\n\n\n\n<li>Gardenia jasminoides J. Ellis extract GJ-4 attenuates hyperlipidemic vascular dementia in rats via regulating PPAR-\u03b3-mediated microglial polarization &#8211; PMC &#8211; PubMed Central, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9338452\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9338452\/<\/a><\/li>\n\n\n\n<li>Corticotropin-releasing factor receptor type 2 in the midbrain, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.researchgate.net\/publication\/358943368_Corticotropin-releasing_factor_receptor_type_2_in_the_midbrain_critically_contributes_to_the_hedonic_feeding_behavior_of_mice_under_heat_stress\" target=\"_blank\" rel=\"noopener\">https:\/\/www.researchgate.net\/publication\/358943368_Corticotropin-releasing_factor_receptor_type_2_in_the_midbrain_critically_contributes_to_the_hedonic_feeding_behavior_of_mice_under_heat_stress<\/a><\/li>\n\n\n\n<li>Uncoupling Protein UCP1 Research Articles &#8211; R Discovery, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/discovery.researcher.life\/topic\/uncoupling-proteins-ucp2\/8932282?page=1\" target=\"_blank\" rel=\"noopener\">https:\/\/discovery.researcher.life\/topic\/uncoupling-proteins-ucp2\/8932282?page=1<\/a><\/li>\n\n\n\n<li>Mitochondrial Biogenesis and Peroxisome Proliferator\u2013Activated Receptor-\u03b3 Coactivator-1\u03b1 (PGC-1\u03b1) Deacetylation by Physical Activity: Intact Adipocytokine Signaling Is Required, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3012167\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3012167\/<\/a><\/li>\n\n\n\n<li>The Role of PGC-1\u03b1 and Mitochondrial Biogenesis in Kidney Diseases &#8211; MDPI, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.mdpi.com\/2218-273X\/10\/2\/347\" target=\"_blank\" rel=\"noopener\">https:\/\/www.mdpi.com\/2218-273X\/10\/2\/347<\/a><\/li>\n\n\n\n<li>PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure &#8211; PMC &#8211; PubMed Central, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3627054\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3627054\/<\/a><\/li>\n\n\n\n<li>PGC-1\u03b1-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart Failure &#8211; Frontiers, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.frontiersin.org\/journals\/cell-and-developmental-biology\/articles\/10.3389\/fcell.2022.871357\/full\" target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/journals\/cell-and-developmental-biology\/articles\/10.3389\/fcell.2022.871357\/full<\/a><\/li>\n\n\n\n<li>Isolation of Calenduloside E from Achyranthes bidentata Blume and its effects on LPS\/D-GalN-induced acute liver injury in mice by regulating the AMPK-SIRT3 signaling pathway &#8211; Bohrium, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.bohrium.com\/paper-details\/isolation-of-calenduloside-e-from-achyranthes-bidentata-blume-and-its-effects-on-lps-d-galn-induced-acute-liver-injury-in-mice-by-regulating-the-ampk-sirt3-signaling-pathway\/952027536592732162-9143\" target=\"_blank\" rel=\"noopener\">https:\/\/www.bohrium.com\/paper-details\/isolation-of-calenduloside-e-from-achyranthes-bidentata-blume-and-its-effects-on-lps-d-galn-induced-acute-liver-injury-in-mice-by-regulating-the-ampk-sirt3-signaling-pathway\/952027536592732162-9143<\/a><\/li>\n\n\n\n<li>GABA A receptor \u03b15 subunit &#8211; IUPHAR\/BPS Guide to PHARMACOLOGY, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=408\" target=\"_blank\" rel=\"noopener\">https:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=408<\/a><\/li>\n\n\n\n<li>Involvement of PGC-1\u03b1 in the Formation and Maintenance of Neuronal Dendritic Spines, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4091730\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4091730\/<\/a><\/li>\n\n\n\n<li>Sertraline &#8211; Wikipedia, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/en.wikipedia.org\/wiki\/Sertraline\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Sertraline<\/a><\/li>\n\n\n\n<li>5-HT1A receptor &#8211; Wikipedia, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/en.wikipedia.org\/wiki\/5-HT1A_receptor\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/5-HT1A_receptor<\/a><\/li>\n\n\n\n<li>5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants &#8211; PMC &#8211; PubMed Central, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2941196\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2941196\/<\/a><\/li>\n\n\n\n<li>5HT1A Autoreceptors &#8211; YouTube, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/m.youtube.com\/watch?v=KWnR9_Zsd9c&amp;pp=ygUPI21vaGFyZHJlY2VwdG9y\" target=\"_blank\" rel=\"noopener\">https:\/\/m.youtube.com\/watch?v=KWnR9_Zsd9c&amp;pp=ygUPI21vaGFyZHJlY2VwdG9y<\/a><\/li>\n\n\n\n<li>Effects of tryptophan depletion in depression Effects of tryptophan, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.researchgate.net\/figure\/Effects-of-tryptophan-depletion-in-depression-Effects-of-tryptophan-depletion-in_tbl1_12003990\" target=\"_blank\" rel=\"noopener\">https:\/\/www.researchgate.net\/figure\/Effects-of-tryptophan-depletion-in-depression-Effects-of-tryptophan-depletion-in_tbl1_12003990<\/a><\/li>\n\n\n\n<li>Convergent Mechanisms Underlying Rapid &#8230; &#8211; SciSpace, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/scispace.com\/pdf\/convergent-mechanisms-underlying-rapid-antidepressant-action-3a7e0votqm.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/scispace.com\/pdf\/convergent-mechanisms-underlying-rapid-antidepressant-action-3a7e0votqm.pdf<\/a><\/li>\n\n\n\n<li>Antidepressive Effects of Kamishoyosan through 5 &#8230; &#8211; SciSpace, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/scispace.com\/pdf\/antidepressive-effects-of-kamishoyosan-through-5-28wv48fwlm.pdf\" target=\"_blank\" rel=\"noopener\">https:\/\/scispace.com\/pdf\/antidepressive-effects-of-kamishoyosan-through-5-28wv48fwlm.pdf<\/a><\/li>\n\n\n\n<li>Serum BDNF Increase After 9-Month Contemplative Mental Training Is Associated With Decreased Cortisol Secretion and Increased Dentate Gyrus Volume: Evidence From a Randomized Clinical Trial &#8211; PubMed, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39896238\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/39896238\/<\/a><\/li>\n\n\n\n<li>Comparison of the Growth Efficiency and Bioactive Compounds of Achyranthes japonica Nakai according to the Sowing Amount in Vertical Farms &#8211; \uc6d0\uc608\uacfc\ud559\uae30\uc220\uc9c0, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.hst-j.org\/articles\/article\/92dW\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.hst-j.org\/articles\/article\/92dW\/<\/a><\/li>\n\n\n\n<li>(PDF) Formulation and Evaluation of Achyranthes bidentata Root Extract Based Herbal-insecticide &#8211; ResearchGate, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.researchgate.net\/publication\/385950323_Formulation_and_Evaluation_of_Achyranthes_bidentata_Root_Extract_Based_Herbal-insecticide\" target=\"_blank\" rel=\"noopener\">https:\/\/www.researchgate.net\/publication\/385950323_Formulation_and_Evaluation_of_Achyranthes_bidentata_Root_Extract_Based_Herbal-insecticide<\/a><\/li>\n\n\n\n<li>Roasting-Induced Enhancement of Antioxidant and Whitening Effects in Achyranthes bidentata Root Extracts &#8211; ResearchGate, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.researchgate.net\/publication\/390217063_Roasting-Induced_Enhancement_of_Antioxidant_and_Whitening_Effects_in_Achyranthes_bidentata_Root_Extracts\" target=\"_blank\" rel=\"noopener\">https:\/\/www.researchgate.net\/publication\/390217063_Roasting-Induced_Enhancement_of_Antioxidant_and_Whitening_Effects_in_Achyranthes_bidentata_Root_Extracts<\/a><\/li>\n\n\n\n<li>Optimizing the Salt-Processing Parameters of Achyranthes bidentata and Their Correlation with Anti-Osteoarthritis Effect &#8211; MDPI, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.mdpi.com\/2227-9717\/12\/3\/434\" target=\"_blank\" rel=\"noopener\">https:\/\/www.mdpi.com\/2227-9717\/12\/3\/434<\/a><\/li>\n\n\n\n<li>Efficacy and acceptability of anti-inflammatory agents in major depressive disorder: a systematic review and meta-analysis &#8211; Frontiers, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.frontiersin.org\/journals\/psychiatry\/articles\/10.3389\/fpsyt.2024.1407529\/full\" target=\"_blank\" rel=\"noopener\">https:\/\/www.frontiersin.org\/journals\/psychiatry\/articles\/10.3389\/fpsyt.2024.1407529\/full<\/a><\/li>\n\n\n\n<li>Role of Interleukin-6 in Depressive Disorder &#8211; PMC &#8211; PubMed Central, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7139933\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7139933\/<\/a><\/li>\n\n\n\n<li>IL-6 inhibition in patients with depression and low-grade inflammation: the Insight study, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.isrctn.com\/ISRCTN16942542?q&amp;filters=trialStatus:Ongoing&amp;sort&amp;offset=2&amp;totalResults=1965&amp;page=1&amp;pageSize=10&amp;searchType=basic-search\" target=\"_blank\" rel=\"noopener\">https:\/\/www.isrctn.com\/ISRCTN16942542?q=&amp;filters=trialStatus:Ongoing&amp;sort=&amp;offset=2&amp;totalResults=1965&amp;page=1&amp;pageSize=10&amp;searchType=basic-search<\/a><\/li>\n\n\n\n<li>Study Results | A Study of the Neurobiology of Depression &#8211; ClinicalTrials.gov, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT01051466?tab=results\" target=\"_blank\" rel=\"noopener\">https:\/\/clinicaltrials.gov\/study\/NCT01051466?tab=results<\/a><\/li>\n\n\n\n<li>Depression linked to internal jet lag study finds &#8211; The University of Sydney, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.sydney.edu.au\/news-opinion\/news\/2025\/07\/16\/depression-linked-to-internal-jet-lag-study-finds.html\" target=\"_blank\" rel=\"noopener\">https:\/\/www.sydney.edu.au\/news-opinion\/news\/2025\/07\/16\/depression-linked-to-internal-jet-lag-study-finds.html<\/a><\/li>\n\n\n\n<li>Structural changes in the hippocampus in major depressive disorder: contributions of disease and treatment &#8211; PMC, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2928287\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2928287\/<\/a><\/li>\n\n\n\n<li>The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex &#8211; PMC, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5299163\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5299163\/<\/a><\/li>\n\n\n\n<li>Autism &#8211; Neuropathology, Genetics, Diagnosis &#8211; Britannica, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.britannica.com\/science\/autism\/Neurodevelopmental-features\" target=\"_blank\" rel=\"noopener\">https:\/\/www.britannica.com\/science\/autism\/Neurodevelopmental-features<\/a><\/li>\n\n\n\n<li>Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications &#8211; PMC &#8211; PubMed Central, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9167750\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9167750\/<\/a><\/li>\n\n\n\n<li>Metabolomics Analysis Reveals the Differences Between Bupleurum chinense DC. and Bupleurum scorzonerifolium Willd &#8211; PMC, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9328751\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9328751\/<\/a><\/li>\n\n\n\n<li>Gene regulation patterns in triterpene biosynthetic pathway driven by overexpression of squalene synthase and methyl jasmonate elicitation in Bupleurum falcatum &#8211; PubMed, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21053012\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pubmed.ncbi.nlm.nih.gov\/21053012\/<\/a><\/li>\n\n\n\n<li>Integrated physiological, transcriptomics and metabolomics analysis revealed the molecular mechanism of Bupleurum chinense seedlings to drought stress &#8211; PMC &#8211; PubMed Central, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11156411\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11156411\/<\/a><\/li>\n\n\n\n<li>Repair of 8-Oxodeoxyguanosine Lesions in Mitochondrial DNA Depends on the Oxoguanine DNA Glycosylase (OGG1) Gene and 8-Oxoguanine Accumulates in the Mitochondrial DNA of OGG1-defective Mice | Request PDF &#8211; ResearchGate, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/www.researchgate.net\/publication\/11886541_Repair_of_8-Oxodeoxyguanosine_Lesions_in_Mitochondrial_DNA_Depends_on_the_Oxoguanine_DNA_Glycosylase_OGG1_Gene_and_8-Oxoguanine_Accumulates_in_the_Mitochondrial_DNA_of_OGG1-defective_Mice\" target=\"_blank\" rel=\"noopener\">https:\/\/www.researchgate.net\/publication\/11886541_Repair_of_8-Oxodeoxyguanosine_Lesions_in_Mitochondrial_DNA_Depends_on_the_Oxoguanine_DNA_Glycosylase_OGG1_Gene_and_8-Oxoguanine_Accumulates_in_the_Mitochondrial_DNA_of_OGG1-defective_Mice<\/a><\/li>\n\n\n\n<li>The protective effects of Achyranthes bidentata root extract on the antimycin A induced damage of osteoblastic MC3T3-E1 cells &#8211; PubMed Central, \u6aa2\u7d22\u65e5\u671f\uff1a7\u6708 25, 2025\uff0c <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4235941\/\" target=\"_blank\" rel=\"noopener\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4235941\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u5831\u544a\u65e8\u5728\u5c0d\u6240\u63d0\u51fa\u7684\u300c\u7761\u7720-\u80fd\u91cf\u8abf\u63a7\u6a21\u578b\u300d\u9032\u884c\u6df1\u5165\u7684\u79d1\u5b78\u5be9\u8996\u8207\u4fee\u6b63\uff0c\u8a72\u6a21\u578b\u65e8\u5728\u6574\u5408\u5206\u5b50\u751f\u7269\u5b78\u8b49\u64da\uff0c\u5c07\u6a5f\u5236\u5ef6\u4f38\u81f3\u7126\u616e\u8207\u6291\u9b31\u75c7\u7684\u8eab\u5fc3\u6cbb\u7642\uff0c\u4e26\u69cb\u5efa\u5f9e\u795e\u7d93\u5143\u5230\u5168\u8eab\u8abf\u7bc0\u7684\u79d1\u5b78\u6846\u67b6\u3002\u5831\u544a\u5c07\u63ed\u793a\u539f\u59cb\u6a21\u578b\u4e2d\u5b58\u5728\u7684\u79d1\u5b78\u4e0d\u6e96\u78ba\u4e4b\u8655\uff0c\u7279\u5225\u662f\u91dd\u5c0d\u672a\u4f86\u5e74\u4efd\u7684\u6587\u737b\u5f15\u7528\u548c\u5177\u9ad4\u91cf\u5316\u6578\u64da\u7684\u8072\u7a31\u3002\u57fa\u65bc\u73fe\u6709\u79d1\u5b78\u8b49\u64da\uff0c\u5831\u544a\u5c07\u63d0\u4f9b\u7cbe\u78ba\u7684\u4fee\u6b63\u5efa\u8b70\uff0c\u4e26\u6df1\u5165\u63a2\u8a0e\u7126\u616e\u8207\u6291\u9b31\u75c7\u7684\u5171\u540c\u5206\u5b50\u75c5\u7406\u3001\u4e2d\u85e5\u6cbb\u7642\u7684\u6f5b\u5728\u6a5f\u5236\u3001\u8207\u897f\u85e5\u6cbb\u7642\u7684\u5206\u5b50\u512a\u52e2\u5c0d\u6bd4\uff0c\u4ee5\u53ca\u81e8\u5e8a\u8f49\u5316\u61c9\u7528\u7684\u53ef\u884c\u6027\u3002\u5831\u544a\u5f37\u8abf\uff0c\u5118\u7ba1\u8a72\u6a21\u578b\u5728\u6574\u5408\u591a\u7cfb\u7d71\u75c5\u7406\u65b9\u9762\u5177\u6709\u5275\u65b0\u6f5b\u529b\uff0c\u4f46\u5176\u90e8\u5206\u5177\u9ad4\u6a5f\u5236\u548c\u91cf\u5316\u9810\u671f\u4ecd\u9700\u66f4\u56b4\u8b39\u7684\u5be6\u8b49\u652f\u6301\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[19,17],"class_list":["post-1286","post","type-post","status-publish","format-standard","hentry","category-sleep","tag-19","tag-17"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/otc.com.tw\/wordpress\/wp-json\/wp\/v2\/posts\/1286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/otc.com.tw\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/otc.com.tw\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/otc.com.tw\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/otc.com.tw\/wordpress\/wp-json\/wp\/v2\/comments?post=1286"}],"version-history":[{"count":2,"href":"https:\/\/otc.com.tw\/wordpress\/wp-json\/wp\/v2\/posts\/1286\/revisions"}],"predecessor-version":[{"id":1289,"href":"https:\/\/otc.com.tw\/wordpress\/wp-json\/wp\/v2\/posts\/1286\/revisions\/1289"}],"wp:attachment":[{"href":"https:\/\/otc.com.tw\/wordpress\/wp-json\/wp\/v2\/media?parent=1286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/otc.com.tw\/wordpress\/wp-json\/wp\/v2\/categories?post=1286"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/otc.com.tw\/wordpress\/wp-json\/wp\/v2\/tags?post=1286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}